Results 91 to 100 of about 874,956 (269)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PREDICTIVE MICROBIOLOGY OF FOOD [PDF]

Postępy Mikrobiologii, 2018
Elżbieta Rosiak, Katarzyna Kajak-Siemaszko, Monika Trząskowska, Danuta Kołożyn-Krajewska   +3 more
doaj   +1 more source

Bayesian Optimized Boosted Ensemble models for HR Analytics - Adopting Green Human Resource Management Practices

International Journal of Technology
Employee attrition is considered a persistent and significant problem across all the leading businesses globally. This is evidenced by the fact that the issue negatively impacted not only production but also impeded the ability of businesses to maintain ...
Thavavel Vaiyapuri, Zohra Sbai
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Feature Selection in Socio-Economic Analysis: A Multi-Method Approach for Accurate Predictive Outcomes

International Journal of Crowd Science
Feature selection is a cornerstone in advancing the accuracy and efficiency of predictive models, particularly in nuanced domains like socio-economic analysis. This study explores nine distinct feature selection methods, utilizing a heart disease dataset
Ahmad Al-Qerem, Ali Mohd Ali, Issam Jebreen, Ahmad Nabot, Mohammed Rajab, Mohammad Alauthman, Amjad Aldweesh, Faisal Aburub, Someah Alangari, Musab Alzgol   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Prediction of Tail Strike Incidents in Flight Training Using Ensemble Learning Models

Aerospace
To achieve accurate predictions of tail strike events during the landing phase of flight training, we propose a stacking ensemble learning prediction model that uses Random Forest (RF), Support Vector Regression (SVR), K-Nearest Neighbors (KNN), and ...
Xing Du, Gang Xu, Kai Zhang, Huibin Jin, Bin Chen   +4 more
doaj   +1 more source

A model of bankruptcy prediction

, 2001
By this thesis Eivind Bernhardsen completed his cand.oecon. degree at the University of Oslo. The thesis was financed by Norges Bank and was written as a part of a project on the development of supervisory credit risk models.
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source