Results 71 to 80 of about 874,956 (269)

Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems

Frontiers in Bioengineering and Biotechnology
Cell-based therapies represent the current frontier of biomedical innovations, with the technologies required underpinning treatments as broad as CAR-T cell therapies, stem cell treatments, genetic therapies and mRNA manufacture.
Elliot J. Morley, Claire L. Brockett, Claire L. Brockett, Stefaan W. Verbruggen, Stefaan W. Verbruggen, Stefaan W. Verbruggen, Stefaan W. Verbruggen   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Machine Learning in Radiation Oncology: Opportunities, Requirements, and Needs

Frontiers in Oncology, 2018
Machine learning (ML) has the potential to revolutionize the field of radiation oncology, but there is much work to be done. In this article, we approach the radiotherapy process from a workflow perspective, identifying specific areas where a data ...
Mary Feng, Gilmer Valdes, Nayha Dixit, Timothy D. Solberg   +3 more
doaj   +1 more source

Self-Organisation of Prediction Models

Entropy, 2023
Living organisms are active open systems far from thermodynamic equilibrium. The ability to behave actively corresponds to dynamical metastability: minor but supercritical internal or external effects may trigger major substantial actions such as gross mechanical motion, dissipating internally accumulated energy reserves.
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Data-Driven Insights into Concrete Flow and Strength: Advancing Smart Material Design Using Machine Learning Strategies

Buildings
Concrete plays a pivotal role in modern methods of construction due to its enhanced strength, durability, and adaptability to advanced building technologies.
Muwaffaq Alqurashi
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Development and validation of machine learning models predicting hospitalizations of hypertensive patients over 12 months

Кардиоваскулярная терапия и профилактика
Aim. To develop models for predicting hospitalizations of hypertensive (HTN) over 12 months using machine learning algorithms and to validate them using real-world practice data.Material and methods.
A. E. Andreychenko, A. D. Ermak, D. V. Gavrilov, R. E. Novitsky, O. M. Drapkina, A. V. Gusev   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Plastron‐mounted loggers predict terrestrial turtle body temperature better than carapace‐mounted loggers

Wildlife Society Bulletin, 2019
Studies of thermal ecology are imperative for understanding habitat use and selection by animals and can inform management decisions for conservation of species and habitat. Chelonian thermal ecology studies have used carapace measurements as proxies for
Adam F. Parlin, Paul J. Schaeffer
doaj   +1 more source