Results 91 to 100 of about 1,054,636 (275)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
BiomimeticsThe predictive brain hypothesis suggests that perception can be interpreted as the process of minimizing the error between predicted perception tokens generated via an internal world model and actual sensory input tokens.
Jan Steckel, Wouter Jansen, Nico Huebel
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers
eLifePsychosis is characterized by a diminished ability of the brain to distinguish externally driven activity patterns from self-generated activity patterns.
Matthias Heindorf, Georg B Keller
doaj +1 more source
Predictive Processing, Implicit and Explicit
, 2022 Preprint artykułu, który ukaże się w pracy zbiorowej: R. Thompson (ed). Routledge Handbook of Philosophy of Implicit Cognition. Routledge.
openaire +5 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
As One and Many: Relating Individual and Emergent Group-Level Generative Models in Active Inference
EntropyActive inference under the Free Energy Principle has been proposed as an across-scales compatible framework for understanding and modelling behaviour and self-maintenance.
Peter Thestrup Waade +6 more
doaj +1 more source
Analyzing the Language of Food on Social Media
, 2014 We investigate the predictive power behind the language of food on social media. We collect a corpus of over three million food-related posts from Twitter and demonstrate that many latent population characteristics can be directly predicted from this ...
Bell, Dane +4 more
core +1 more source
Learned Predictiveness Speeds Visual Processing
Psychological Science, 2012 When humans learn that the presence of a cue predicts the likelihood of an outcome, they can exploit this learned predictiveness, such that formation of subsequent associations between that cue and new outcomes is facilitated. Could such enhanced selection for association arise early enough to facilitate low-level visual processing?
O'Brien, Jennifer L., Raymond, Jane E.
openaire +2 more sources