Results 71 to 80 of about 7,717,977 (381)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Predictive Validity of Reproductive Intentions [PDF]

Demography, 1977
Abstract On the basis of data collected in the 1975 National Fertility Study (NFS) in which continuously married white women interviewed in the 1970 NFS were reinterviewed five years later, the aggregate and individual validity of reported fertility intentions is evaluated.
C F, Westoff, N B, Ryder
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Fluctuation relations for systems in constant magnetic field

, 2020
The validity of the Fluctuation Relations (FR) for systems in a constant magnetic field is investigated. Recently introduced time-reversal symmetries that hold in presence of static electric and magnetic fields and of deterministic thermostats are used ...
Bonella, Sara, Coretti, Alessandro, Rondoni, Lamberto   +2 more
core   +1 more source

(368) Predictive Validity of the Kansas City Cardiomyopathy Questionnaire in Adults with Congenital Heart Disease [PDF]

, 2023
R.D. Byrne, S.J. Dolgner, Anoop K Nair, C. Broda   +3 more
openalex   +1 more source

Illness Perceptions Predict Cognitive Performance Validity [PDF]

Journal of the International Neuropsychological Society, 2018
AbstractObjectives:The aim of this study was to investigate the relationship of psychological variables to cognitive performance validity test (PVT) results in mixed forensic and nonforensic clinical samples.Methods:Participants included 183 adults who underwent comprehensive neuropsychological examination.
George K, Henry, Robert L, Heilbronner, Julie, Suhr, Jeffrey, Gornbein, Eveleigh, Wagner, Daniel L, Drane   +5 more
openaire   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Are the Results of the Bayley Scales of Infant and Toddler Development (Third Edition) Predictive for Later Motor Skills and School Performance?

Children
Background/Objectives: The first year of life represents a critical developmental stage in which the foundations for motor, cognitive, language, and social–emotional development are set.
Sophia Maria Kipping, Wieland Kiess, Juliane Ludwig, Christof Meigen, Tanja Poulain   +4 more
doaj   +1 more source