Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Negative Predictive Value of Pap Testing [PDF]
, 2012 ObjectiveTo estimate the accuracy of Pap testing for women who are human immunodeficiency virus (HIV)-seropositive, with a focus on negative predictive value.MethodsParticipants in the Women's Interagency HIV Study were monitored with conventional Pap tests every 6 months.
Massad, L Stewart +7 more
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Signal Intensity of High B-value Diffusion-weighted Imaging for the Detection of Prostate Cancer
Journal of Biomedical Physics and Engineering, 2019 Background: Diffusion-weighted imaging (DWI) is a main component of multiparametric MRI for prostate cancer detection. Recently, high b value DWI has gained more attention because of its capability for tumor characterization. Objective: To assess based
Rezaeian A. +5 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Metabolic-associated fatty liver disease is less effective in predicting mortality than non-alcoholic fatty liver disease and metabolic dysfunction-associated steatotic liver disease: Letter to the editor on “Prognosis of biopsy-confirmed metabolic dysfunction-associated steatotic liver disease: A sub-analysis of the CLIONE study” [PDF]
Clinical and Molecular HepatologyYixuan Zhu +5 more
doaj +1 more source
Predictive value of glucose tolerance test
Kazan medical journal, 1982 Abstract. A retrospective analysis of the long-term observation of the dynamics of normal glucose tolerance in 564 women was carried out. Re-examination revealed violations of tolerance in 33.8% (of doubtful type in 25.7% and of diabetic type in 8.1%).
openaire +1 more source
Ascitic fluid analysis for the differentiation of malignancy related and nonmalignant ascites [PDF]
, 1991 The authors tried to differentiate malignancy-related from nonmalignant ascites with a sequence of sensitive followed by specific ascitic-fluid parameters. There were four results of this study. First, of nine parameters investigated in a first series of
Paumgartner, Gustav +4 more
core
An evaluation of the predictive value of temperament tests carried out on Assistance Hearing Dogs
, 2016 Assistance Hearing Dogs provide independence to people with a hearing impairment by alerting to household and danger sounds, and provide companionship in a range of public places. Hearing Dogs experience thorough socialising and training in order to meet
Hannah Plant (18247621)
core +1 more source