Results 81 to 90 of about 936,691 (247)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Value of dynamic changes in inflammatory biomarkers for predicting intravenous immunoglobulin resistance in children with Kawasaki disease

Frontiers in Immunology
PurposeThis study assessed the predictive value of dynamic laboratory parameter changes before and after intravenous immunoglobulin (IVIG) treatment for IVIG resistance in children with Kawasaki disease (KD).MethodsChildren with KD were stratified based ...
Zhiyuan Liu, Yidan Zhang, PanPan Liu, Weiguo Qian, Qiuqin Xu, Miao Hou, Ying Liu, Guanghui Qian, Jiajia Tan, Qianzi Ge, Mingyang Zhang, Jing Li, Sheng Zhao, Haitao Lv, Shuhui Wang   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

CLINICAL AND X-RAY SPECIFICS OF SARCOIDOSIS DETECTED IN TUBERCULOSIS CONTROL SERVICES

Туберкулез и болезни лёгких, 2015
The  current diffculties of  differential diagnostics of  pulmonary sarcoidosis have been analyzed in  58 patients. The  duration of the diagnostic period has been described.
Zh. A. Laushkina, V. A. Krasnov, P. N. Filimonov   +2 more
doaj  

The heterogeneous life space trajectories and predictors in stroke patients: a cohort study

Frontiers in Neurology
ObjectiveThis study aimed to identify heterogeneous trajectories of life space among stroke patients and explore the predictors for different classes of life space.MethodsThis prospective cohort study assessed 210 stroke patients’ life space at baseline ...
Bei Yang, Bei Yang, Rui Xie, Siyuan Ge, Ruixue Tang, Kangyao Cheng, Yin Wang   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diagnostic Delay and its Predictors among Tuberculosis Patients in Kandahar, Afghanistan: A Cross-sectional Analytical Study

International Journal of Mycobacteriology
Background: Diagnostic delay among tuberculosis (TB) patients leads to late anti-TB treatment initiation, which is associated with poor prognosis and increased TB transmission.
Hazratullah Bariz, Muhammad Haroon Stanikzai, Ghulam Mohayuddin Mudaser, Khalid Ahmad Stanikzai, Omid Dadras   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Sensors and Sensing Methods for Early Detection of Life-Threatening Sudden Illnesses in Motor Vehicles Drivers

Engineering Proceedings
Due to the increasing number of vehicles and the aging population, the vulnerability to sudden medical emergencies among drivers is a growing problem. Events such as heart attack, stroke, and loss of consciousness can occur without warning and endanger ...
Hristo Radev, Galidiya Petrova
doaj   +1 more source