Results 31 to 40 of about 6,333 (261)

Computational study on the effects of solvent and thermodynamic properties of the pharmaceutical compound milrinone in aqueous solutions of ethanol and 2-propanol

Chemical Thermodynamics and Thermal Analysis
In this study, the Kamlet–Abboud–Taft linear solvation energy relationship (KAT-LSER) model, van't Hoff analysis, and Inverse Kirkwood-Buff Integrals method were applied to determine solvent effects, dissolution thermodynamics, and preferential solvation
Adel Noubigh, Mustafa Jaipallah Abualreish, Manef Abderrabba   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The solvent effect, preferential solvation of metformin hydrochloride in binary mixed solvents of methanol/ethanol + water mixtures from 278.15 K to 323.15 K

South African Journal of Chemical Engineering
This study provides a novel quantitative analysis of metformin hydrochloride (MET-HCl) solvation behavior in binary solvents mixtures of methyl alcohol and water, as well as ethyl alcohol and water, addressing critical gaps in understanding its ...
Adel Noubigh, Abdalazeem A. Omar, Manef Abderrabba   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Dissolution Thermodynamics and Preferential Solvation of Phenothiazine in Some Aqueous Cosolvent Systems

Liquids
Published equilibrium mole fraction solubilities of phenothiazine in ethanol, propylene glycol and water as mono-solvents at several temperatures were investigated to find standard apparent thermodynamic quantities of dissolution mixing and solvation ...
Fleming Martínez, María Ángeles Peña, Abolghasem Jouyban   +2 more
doaj   +1 more source

Molecular mechanisms induced by phase modifiers used in hydrometallurgy: consequences on transfer efficiency and process safety

Comptes Rendus. Chimie, 2022
It is a matter of strategic independence for many countries to urgently find processes that take into account environmental and economic issues when recycling critical metals. Liquid–liquid (L/L) extraction is a promising method for recovering rare-earth
El Maangar, Asmae, Prévost, Sylvain, Dourdain, Sandrine, Zemb, Thomas   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Simulation and mathematical analysis of L-Cysteine's transfer properties and solvation behavior in mixed water–alcohol solutions

Chemical Thermodynamics and Thermal Analysis
We investigated preferential solvation of L-Cystine (L-Cys) in two aqueous co-solvent systems (methanol (MeOH) and ethanol (EtOH)), utilizing the mole percentage solubility data provided.
Adel Noubigh, Rafik Tayeb, Amani A.S. Abdelaziz   +2 more
doaj   +1 more source