Results 121 to 130 of about 386,459 (384)

Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults. [PDF]

PLoS ONE, 2014
Although altered function in neural reward circuitry is widely proposed in models of addiction, more recent conceptual views have emphasized the role of disrupted response in prefrontal regions. Changes in regions such as the orbitofrontal cortex, medial
Erika E Forbes, Eric E Rodriguez, Samuel Musselman, Rajesh Narendran   +3 more
doaj   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2015
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P., Kantak, Kathleen M., Somkuwar, Sucharita S.   +2 more
core   +4 more sources

Somatosensory and Visual Deprivation Each Decrease the Density of Parvalbumin Neurons and Their Synapse Terminals in the Prefrontal Cortex and Hippocampus of Mice [PDF]

, 2013
In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-
Okamoto, Motoi, Shoshi, Chikafumi, Suemitsu, Shunsuke, Sujiura, Hiroko, Ueno, Hiroshi, Usui, Shinichi   +5 more
core   +1 more source

Choline in Pediatric Depression

McGill Journal of Medicine, 2020
Purpose of Study: The prefrontal cortex has been previously implicated in the neuropathology of major depressive disorder (MDD). Hence, we used proton magnetic resonance spectroscopy (1H-MRS) to examine choline levels in the prefrontal cortex of youth ...
Frank P MacMaster, Vivek Kusumakar
doaj   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Anterior Prefrontal Cortex Contributes to Action Selection through Tracking of Recent Reward Trends [PDF]

, 2012
The functions of prefrontal cortex remain enigmatic, especially for its anterior sectors, putatively ranging from planning to self-initiated behavior, social cognition, task switching, and memory.
Adolphs, Ralph, Daw, Nathaniel D., Kovach, Christopher K., O'Doherty, John P., Rudrauf, David, Tranel, Daniel   +5 more
core  

A neuropsychological test of belief and doubt: Damage to ventromedial prefrontal cortex increases credulity for misleading advertising

Frontiers in Neuroscience, 2012
We have proposed the False Tagging Theory as a neurobiological model of belief and doubt processes. The theory posits that the prefrontal cortex is critical for normative doubt toward properly comprehended ideas or cognitions.
Erik eAsp, Kenneth eManzel, Bryan eKoestner, Catherine eCole, Natalie L Denburg, Daniel eTranel   +5 more
doaj   +1 more source

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source