Results 41 to 50 of about 199,923 (254)

Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior

Biological Research
Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal
Ignacio Negrón-Oyarzo, Ariel Lara-Vásquez, Ismael Palacios-García, Pablo Fuentealba, Francisco Aboitiz   +4 more
doaj   +1 more source

Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex

Cell Reports, 2018
Summary: Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may ...
Marie H. Sabec, Susan Wonnacott, E. Clea Warburton, Zafar I. Bashir   +3 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory. [PDF]

PLoS ONE, 2014
Prefrontal behavior and activity in humans are heritable. Studies in animals demonstrate an interaction between dopamine D2 receptors and nicotinic acetylcholine receptors on prefrontal behavior but evidence in humans is weak.
Annabella Di Giorgio, Ryan M Smith, Leonardo Fazio, Enrico D'Ambrosio, Barbara Gelao, Aldo Tomasicchio, Pierluigi Selvaggi, Paolo Taurisano, Tiziana Quarto, Rita Masellis, Antonio Rampino, Grazia Caforio, Teresa Popolizio, Giuseppe Blasi, Wolfgang Sadee, Alessandro Bertolino   +15 more
doaj   +1 more source

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov, Alexander F. Santillo, Patrick R. Hof   +2 more
wiley   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Resting-state coupling between core regions within the central-executive and salience networks contributes to working memory performance

Frontiers in Behavioral Neuroscience, 2016
Previous studies investigated the distinct roles played by different cognitive regions and suggested that the patterns of connectivity of these regions are associated with working memory.
Xiaojing eFang, Yuanchao eZhang, Yuan eZhou, Luqi eCheng, Jin eLi, Yulin eWang, Karl eFriston, Tianzi eJiang, Tianzi eJiang, Tianzi eJiang, Tianzi eJiang, Tianzi eJiang   +11 more
doaj   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source