Results 61 to 70 of about 207,019 (253)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

The dynamics of disordered dialogue: Prefrontal, hippocampal and thalamic miscommunication underlying working memory deficits in schizophrenia

Brain and Neuroscience Advances, 2018
The prefrontal cortex is central to the orchestrated brain network communication that gives rise to working memory and other cognitive functions. Accordingly, working memory deficits in schizophrenia are increasingly thought to derive from prefrontal ...
David A Kupferschmidt, Joshua A Gordon
doaj   +1 more source

The Lateral Prefrontal Cortex and Selection/Inhibition in ADHD

Frontiers in Human Neuroscience, 2018
A previous paper from our lab (Shalom, 2009) presented evidence that the medial part of the prefrontal cortex is involved in the integration of raw, unintegrated information into coherent, wholistic mental representations such as perceptual objects ...
Ziv Ronel
doaj   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

N-acetyl-aspartate level is decreased in the prefrontal cortex in subjects at-risk for schizophrenia.

Frontiers in Psychiatry, 2013
Reduced N-Acetyl-Aspartate (NAA) levels have been reported in the prefrontal cortex in patients with schizophrenia using proton magnetic resonance spectroscopy.
Marine eMondino, Jerome eBrunelin, Mohamed eSAOUD   +2 more
doaj   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Prefrontal Abilities

Behavioural Neurology, 1993
The neuroanatomical region that has most prominently altered with the advancing cognitive competency of the human is the prefrontal cortex, particularly the rostral extreme.
D. F. Benson
doaj   +1 more source

Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys

eLife, 2019
The interactions of anterior temporal structures, and especially the amygdala, with the prefrontal cortex are pivotal to learning, decision-making, and socio-emotional regulation.
Davide Folloni, Jerome Sallet, Alexandre A Khrapitchev, Nicola Sibson, Lennart Verhagen, Rogier B Mars   +5 more
doaj   +1 more source