Results 81 to 90 of about 591,591 (296)

A common neural system mediating two different forms of social judgement [PDF]

, 2009
Background: A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function.
Santos, I. M., D. I. Donaldson, Donaldson, David, Whalley, H. C., Lawrie, Stephen M, J. W. Mckirdy, Santos, Isabel M, Donaldson, D. I., McGonigle, D. J., R. Sprengelmeyer, I. M. Santos, Hall, J., S. M. Lawrie, Sprengelmeyer, R., A. M. Mcintosh, Whalley, Heather C, Sprengelmeyer, Reiner, Johnstone, Eve C, McIntosh, Andrew M, McKirdy, J. W., J. Hall, McIntosh, A. M., A. W. Young, E. C. Johnstone, Young, A. W., H. C. Whalley, McKirdy, James W, McGonigle, David, Johnstone, E. C., Lawrie, S. M., Hall, Jeremy, D. J. Mcgonigle, Young, Andrew W, Sprengelmeyer, R.; id_orcid   +33 more
core   +1 more source

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source

Prefrontal cortical thickness in motor neuron disease

NeuroImage: Clinical, 2018
Objective: To examine whether the distribution of prefrontal cortical thickness in patients with motor neuron disease is normal or bimodal and how it compares to the normal population.
Judith Machts, Arturo Cardenas-Blanco, Julio Acosta-Cabronero, Joern Kaufmann, Kristian Loewe, Elisabeth Kasper, Christina Schuster, Johannes Prudlo, Stefan Vielhaber, Peter J. Nestor   +9 more
doaj   +1 more source

Using e-greedy reinforcement learning methods to further understand ventromedial prefrontal patients' deficits on the Iowa Gambling Task [PDF]

, 2005
An important component of decision making is the process of choosing from a set of options. This choice is often based on an evaluation of the potential costs or benefits of selecting an option, its estimated reward value.
Kalidindi, Kiran, Wyble, Brad, Bowman, Howard   +2 more
core  

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study

Scientific Reports
This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT).
Lan Mou, Yuqi Shen, Boyuan Wu, Chengyu Zhang, Jiayun Zhu, Qian Tan, Xiaomei Zhang, Zefeng Wang, Zhongxia Shen   +8 more
doaj   +1 more source

The Lateral Prefrontal Cortex and Selection/Inhibition in ADHD

Frontiers in Human Neuroscience, 2018
A previous paper from our lab (Shalom, 2009) presented evidence that the medial part of the prefrontal cortex is involved in the integration of raw, unintegrated information into coherent, wholistic mental representations such as perceptual objects ...
Ziv Ronel
doaj   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Attentional preparation for a lateralized visual distractor: Behavioral and fMRI evidence [PDF]

, 2006
Attending to the location of all expected visual target call lead to anticipatory activations In spatiotopic occipital cortex, emerging before target onset.
Christian C. Ruff, Ruff, CC, Jon Driver, Driver, J   +3 more
core   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source