Results 71 to 80 of about 591,591 (296)
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
PLoS ONE, 2019 Allergic rhinitis is a chronic inflammatory disease of the upper respiratory tract, which is associated with high incidence of anxiety symptom. There is evidence that medial prefrontal cortex modulates anxiety-related behaviors and receives projections ...
Morteza Salimi +8 more
doaj +1 more source
An investigation of the myopia for future consequences theory of VMF patient behaviour on the Iowa Gambling Task: An abstract neural network simulation [PDF]
, 2005 Somatic marker theory proposes that body states act as a valence associated with potential choices based on prior outcomes; and thus aid decision-making.
Kalidindi, Kiran +5 more
core +1 more source
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
The Anterior Prefrontal Cortex and the Hippocampus Are Negatively Correlated during False Memories
Brain Sciences, 2017 False memories commonly activate the anterior/dorsolateral prefrontal cortex (A/DLPFC) and the hippocampus. These regions are assumed to work in concert during false memories, which would predict a positive correlation between the magnitudes of activity ...
Brittany M. Jeye +2 more
doaj +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Brain and BehaviorEmerging evidences suggest that cognitive deficits in individuals with mild cognitive impairment (MCI) are associated with disruptions in brain functional connectivity (FC).
Shuangyan Wang +3 more
doaj +1 more source
Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates
Advanced Science, EarlyView.Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta +3 more
wiley +1 more source
Increased firing irregularity as an emergent property of neural-state transition in monkey prefrontal cortex. [PDF]
PLoS ONE, 2013 Flexible behaviors are organized by complex neural networks in the prefrontal cortex. Recent studies have suggested that such networks exhibit multiple dynamical states, and can switch rapidly from one state to another.
Kazuhiro Sakamoto +5 more
doaj +1 more source
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression [PDF]
, 2009 DTNBP1 (dystrobrevin binding protein 1) remains one of the top candidate genes in schizophrenia. Reduced expression of this gene and the protein it encodes, dysbindin-1, has been reported in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia ...
Natalia Louneva +8 more
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