Results 71 to 80 of about 114,093,824 (304)

Induced abortion, pregnancy loss and intimate partner violence in Tanzania: a population based study. [PDF]

, 2012
BACKGROUND: Violence by an intimate partner is increasingly recognized as an important public and reproductive health issue. The aim of this study is to investigate the extent to which physical and/or sexual intimate partner violence is associated with ...
Filippi, V., Watts, Charlotte, Stöckl Heidi, Watts Charlotte, Mbwambo, Jessie KK, Watts, C., Jessie KK Mbwambo, Filippi, Veronique, Veronique Filippi, Stöckl, H., Mbwambo, Jessie K K, Mbwambo Jessie KK, Filippi Veronique, Heidi Stöckl, Charlotte Watts, Mbwambo, J.K.K, Stöckl, Heidi   +16 more
core   +2 more sources

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Pre-pregnancy complications-associated factors and wellbeing in early pregnancy : a Swedish cohort study

, 2023
Background: Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more ...
Du, Juan,, Schuppe-Koistinen, Ina,, Gudnadottir, U, Gudnadottir, Unnur, Gudnadottir, Unnur,, Hugerth, LWW, Du, J,, Engstrand, Lars, Itzel, Eva Wiberg,, Hugerth, Luisa W. W., Brusselaers, Nele, Engstrand, L,, Brusselaers, N,, Hugerth, Luisa W. W.,, Fransson, Emma,, Fransson, E,, Itzel, EW, Du, Juan, Schuppe-Koistinen, Ina, Engstrand, Lars,, Brusselaers, Nele,, Schuppe-Koistinen, I, Itzel, Eva Wiberg, Fransson, Emma   +23 more
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

If I were Jack? Adolescent males’ attitudes and decision-making in relation to an unintended pregnancy

, 2012
In 2007, a Research Awards Programme was established by the Crisis Pregnancy Agency for individuals working in academic institutions, not-for-profit research organisations and non-governmental organisations (with a research capacity) wishing to ...
Lohan, Maria, Hyde, Abbey, Alderdice, Fiona, O’Halloran, Peter, Cruise, Sharon   +4 more
core  

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy [PDF]

Acta Medica Academica, 2012
Objective. The aim of the study: To evaluate the correlations betweenZn2+, Cu2+, Mg2+, Se2+ and Cr3+ and alteration in T cell subsetsduring diabetic and normal pregnancy. Methods.
Fadia Mahmoud, Habib Abul, Ali Dashti, Waleed Al-Jassar, Alexander Omu   +4 more
doaj  

Hypertensive disease in pregnancy in women with objectively measured snoring

, 2015
Sleep disordered breathing (SDB) is common in women and reported at 14–45% in pregnancy. SDB is identified by snoring and repetitive cessation of breathing during sleep accompanied by repetitive hypoxia and has been found to be associated with ...
Johnson, Pamela, Sullivan, Colin E., Robertson, Annette J. (R17884), Hennessy, Annemarie (R11780)   +3 more
core   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source