Results 81 to 90 of about 119,898,357 (301)
Advanced Science, EarlyView.The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian +14 more
wiley +1 more source
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
Polycystic ovary syndrome and risk factors for gestational diabetes
Endocrine Connections, 2018 Objective: To study the roles of self-reported symptoms and/or prior diagnosis of polycystic ovary syndrome (PCOS) and other potential risk factors for gestational diabetes mellitus (GDM) and to clarify whether the screening of GDM in early pregnancy is ...
Sanna Mustaniemi +8 more
doaj +1 more source
Crisis pregnancy counselling in Ireland
, 2004 Between September 2002 and September 2003 Dr. Saoirse Nic Gabhainn and Dr. Vivienne Batt of the Centre for Health Promotion Studies and the Women’s Studies Centre, National University of Ireland, Galway conducted research on behalf of the Crisis ...
Nic Gabhainn, Saoirse, Batt, Vivienne
core
The impact of pregnancy on foot health [PDF]
, 2014 Although pregnancy should be a joyous experience to all expectant mothers, it is also known to bring about a number of bodily changes which could impose lifestyle limitations throughout the nine months of pregnancy.
Cassar, Dorothy
core +1 more source
Advanced Science, EarlyView.This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He +14 more
wiley +1 more source
Diabetes in pregnancy among Sri Lankan women: gestational or pre-gestational?
Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2012 Introduction: There is an exponential rise in the occurrence of diabetes during pregnancy in South Asia. However data is sparse on the actual pre-gestational diabetes mellitus (PGDM) versus gestational diabetes mellitus (GDM) case-mix.
KGH Jayathilaka +5 more
doaj +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
Clinical audit in management of pregnant women with diabetes mellitus at Qena University Hospitals
SVU - International Journal of Medical SciencesBackground: Gestational diabetes is type 1 or 2. Preconception treatment reduces problems, while poor blood glucose management increases congenital deformity risk.
Alyaa Badawy Saad* +3 more
doaj +1 more source