Results 51 to 60 of about 770,380 (355)

Advances in the diagnosis and early management of gestational trophoblastic disease

BMJ Medicine, 2022
Gestational trophoblastic disease describes a group of rare pregnancy related disorders that span a spectrum of premalignant and malignant conditions. Hydatidiform mole (also termed molar pregnancy) is the most common form of this disease.
Keelin O'Donoghue, Brendan Fitzgerald, John Coulter, Caroline M Joyce, Tommie V McCarthy   +4 more
doaj   +1 more source

Uterine artery Doppler in the management of early pregnancy loss: a prospective, longitudinal study [PDF]

, 2015
The pharmacological management of early pregnancy loss reduced substantially the need for dilation and curettage. However, prognostic markers of successful outcome were not established.
Almeida, H., Gaio, R., Guedes-Martins, L., Macedo, F., Reynolds, A., Saraiva, J.   +5 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Chronic Endometritis and Uterine Endometrium Microbiota in Recurrent Implantation Failure and Recurrent Pregnancy Loss

Biomedicines, 2023
The aim of this study was to evaluate whether chronic endometritis (CE) and uterine endometrium microbiota were associated with repeated implantation failures (RIFs) and recurrent pregnancy losses (RPLs).
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada   +4 more
doaj   +1 more source

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. [PDF]

, 2018
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few ...
Aagaard, Kjersti M, Adams Waldorf, Kristina M, Ardeshir, Amir, Bliss-Moreau, Eliza, Bohm, Rudolf P, Capuano, Saverio V, Chiu, Charles Y, Coffey, Lark L, Colgin, Lois M, Dudley, Dawn M, Friedrich, Thomas C, Gale, Michael, Gilbert, Margaret H, Golos, Thaddeus G, Grigsby, Peta L, Hirsch, Alec J, Hodge, Travis, Hotchkiss, Charlotte E, Keesler, Rebekah I, MacAllister, Rhonda P, Maness, Nicholas J, Martín, Claudia Sánchez-San, Mejia, Andres, Mohr, Emma L, O'Connor, David H, Panganiban, Antonito T, Patterson, Jean L, Pecoraro, Heidi L, Rajagopal, Lakshmi, Seferovic, Maxim, Simmons, Heather A, Steinbach, Rosemary J, Streblow, Daniel N, Tamhankar, Manasi, Tardif, Suzette, Van Rompay, Koen K, Veazey, Ronald S, Wang, Xiaolei   +37 more
core  

Successful delivery after vaginal occlusion in addition to cerclage in a trachelectomy patient with recurrent second trimester pregnancy loss:a case report [PDF]

, 2014
KEY CLINICAL MESSAGE: Pregnancy outcome after trachelectomy has high risk of complications such as second trimester pregnancy loss and preterm birth.
Langhoff-Roos, Jens, Ottosen, Christian, Poulsen, Mette Østergaard, Sneider, Kirstine   +3 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Recurrent Miscarriage and Infertility Services and Supports: A Qualitative Study of Views and Experiences in the Republic of Ireland

Health Expectations
Background Recurrent miscarriage (RM) and infertility are separately associated with psychological distress and adverse pregnancy outcomes. The dual experience is devastating for women/couples but is not considered in clinical guidance for RM or ...
Laura Aoife Linehan, Marita Hennessy, Keelin O'Donoghue   +2 more
doaj   +1 more source

Serum relaxin levels are reduced in pregnant women with a history of recurrent miscarriage, and correlate with maternal uterine artery Doppler indices in first trimester [PDF]

, 2009
Objectives: Defective implantation is a mechanism for recurrent pregnancy loss (RPL). We sought to determine whether the serum expression of human relaxin-2 (RLX) is impaired in women with a history of RPL.
Bogic, Bogic, Carp, Craig, Dilly O.C. Anumba, Emmer, Gardosi, Goldsmith, Hollis, Jauniaux, Jivraj, Johnson, Johnson, Laird, MacLennan, Maynard, Mtiraoui, Nicolaides, Palomba, Parry, Petersen, Piccinni, Prakash, Saad El Gelany, Sakbun, Salim, Sarah L. Elliott, Seki, Tin C. Li, Unemori, Yki-Jarvinen   +30 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source