Results 171 to 180 of about 10,479 (197)
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ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY
Drug Metabolism and Disposition, 2005The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and rats with inducers of CYP3A increases acetaminophen (APAP) hepatotoxicity. In untreated mice, the amount of hepatic CYP3A11 mRNA is 4-fold greater in PXR(-/-) mice compared to ...
Kristina K, Wolf +17 more
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Pregnane X Receptor: Promiscuous regulator of detoxification pathways
The International Journal of Biochemistry & Cell Biology, 2007The Pregnane X Receptor (PXR) is pivotal for the body's response to toxic xenobiotics and endogenous metabolites. By acting as a ligand-activated transcription factor, PXR regulates all stages of xenobiotic metabolism and transport and is responsible for important inductive drug interactions.
Marko, Matic +5 more
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Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome
Journal of Cellular Physiology, 2014The pregnane X receptor (PXR, NR1I2) is a ligand‐activated nuclear receptor which plays an essential role in organism's metabolic detoxification system by sensing the presence of xenobiotics and triggering detoxification responses. In addition to its role in xenobiotic metabolism, PXR has pleiotropic functions in regulating immune/inflammatory ...
Xi, Ma, Jingshu, Chen, Yanan, Tian
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Pregnane X receptor (PXR) – a contributor to the diabetes epidemic?
dmdi, 2013Abstract Pregnane X receptor (PXR), a ligand-activated nuclear receptor, was originally identified as a regulator of drug and bile acid metabolism. Studies in experimental animals and humans within the last decade have revealed PXR as a regulator of energy metabolism repressing gluconeogenesis and hepatic lipid ...
Janne, Hukkanen +2 more
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Epigenetic regulation of pregnane X receptor activity
Drug Metabolism Reviews, 2013Pregnane X receptor (PXR, NR1I2) is a ligand-dependent nuclear receptor (NR) that functions as a xenobiotic sensor and effector in coordinately regulating expression of genes of the xenobiotic detoxification network. PXR exerts its transcriptional regulatory functions by dimerization with retinoic X receptor RXR, and PXR-RXR complex binds to specific ...
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INDUCTION OF ABCC3 (MRP3) BY PREGNANE X RECEPTOR ACTIVATORS
Drug Metabolism and Disposition, 2003The pregnane X receptor (PXR) mediates the induction of various genes by xenobiotics, including several ATP-binding cassette transporters. PXR is also activated by bile acids likely to prevent their accumulation to toxic levels; however, the role of PXR in the regulation of MRP3, an important bile acid efflux transporter, has not been elucidated.
Shirley, Teng +2 more
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Ligand- and Structure-Based Pregnane X Receptor Models
2012The human pregnane X receptor (PXR) is a ligand dependent transcription factor that can be activated by structurally diverse agonists including steroid hormones, bile acids, herbal drugs, and prescription medications. PXR regulates the transcription of several genes involved in xenobiotic detoxification and apoptosis.
Sandhya, Kortagere +2 more
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Dietary phytochemicals as modulators of human pregnane X receptor
Critical Reviews in Food Science and Nutrition, 2023Petr Pavek +2 more
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