Results 61 to 70 of about 302,104 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Clinical manifestations comparison in hospitalized pregnant and non-pregnant women with Covid-19 at Mataram University Hospital, Mataram, Indonesia

open access: yesMajalah Obstetri dan Ginekologi, 2022
HIGHLIGHTS 1. Clinical manifestations in pregnant and non-pregnant women with Covid-19 were identified. 2. Pregnant women with Covid-19 mostly had asymptomatic clinical manifestations, while non-pregnant women with Covid-19 mostly had symptomatic ...
Putu Diah Ananda Putri Atmaja   +2 more
doaj   +1 more source

Compelled Medical Treatment of Pregnant Women

open access: yes, 1988
The authors discuss the ethical aspects of the relationship between physicians and pregnant patients involving the reconciliation of maternal-fetal conflict.
Milliken, Nancy   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Factors associated with moderate to high nicotine dependence in a sample of Romanian pregnant women

open access: yesTobacco Prevention and Cessation, 2019
Introduction Despite maternal smoking being linked with poor maternal and pregnancy outcomes, 15% of Romanian women continue smoking during pregnancy emphasizing the need for cessation programs.
Marina Denisa Dascal   +3 more
doaj   +1 more source

Occupational stress is associated with job performance among pregnant women in Japan: comparison with similar age group of women

open access: yesBMC Pregnancy and Childbirth, 2022
Background Pregnancy results in physical and psychological changes in women; however, pregnant women hesitate to take a break from work even when they feel the need.
Yasuka Nakamura   +7 more
doaj   +1 more source

Control Behaviors of Fathers and Pregnant Women on Adherence of Pregnant Women to Take Blood Supplement Tablets

open access: yes
Anemia prevention programs in pregnant women often involve the consumption of blood supplement tablets in pregnant women, and an understanding of the role of fathers and pregnant women in supporting adherence is essential to improve the effectiveness of ...
Sutrisni, Sutrisni; Midwifery Study Program D III, Universitas Kadiri, Jawa Timur, Indonesia   +2 more
core   +1 more source

A Qualitative Study of an Integrated Maternity, Drugs and Social Care Service for Drug-using Women [PDF]

open access: yes, 2006
Background: The care of drug-using pregnant women is a growing health and social care concern in many countries. A specialist clinic was established offering multidisciplinary care and advice to pregnant drug users in and around Aberdeen (UK) in 1997 ...
Hall, Jenny   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The determinant of health insurance ownership among pregnant women in Indonesia

open access: yesBMC Public Health, 2021
Background Health insurance ownership is one indicator of the readiness of pregnant women for the delivery process. The study aimed to analyze the determinants of health insurance ownership among pregnant women in Indonesia.
Agung Dwi Laksono   +2 more
doaj   +1 more source

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