Results 51 to 60 of about 4,926,663 (261)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Tuberculosis clinical presentation and treatment outcomes in pregnancy: a prospective cohort study

BMC Infectious Diseases, 2020
Background There is limited research to guide TB treatment specifically in pregnant women and few studies have described the presentation of TB in pregnant women.
Brittney J. van de Water, Meredith B. Brooks, Chuan-Chin Huang, Letizia Trevisi, Leonid Lecca, Carmen Contreras, Jerome Galea, Roger Calderon, Rosa Yataco, Megan Murray, Mercedes C. Becerra   +10 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Clinical manifestations comparison in hospitalized pregnant and non-pregnant women with Covid-19 at Mataram University Hospital, Mataram, Indonesia

Majalah Obstetri dan Ginekologi, 2022
HIGHLIGHTS 1. Clinical manifestations in pregnant and non-pregnant women with Covid-19 were identified. 2. Pregnant women with Covid-19 mostly had asymptomatic clinical manifestations, while non-pregnant women with Covid-19 mostly had symptomatic ...
Putu Diah Ananda Putri Atmaja, Ario Danianto, Titi Pambudi Karuniawaty   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Factors associated with moderate to high nicotine dependence in a sample of Romanian pregnant women

Tobacco Prevention and Cessation, 2019
Introduction Despite maternal smoking being linked with poor maternal and pregnancy outcomes, 15% of Romanian women continue smoking during pregnancy emphasizing the need for cessation programs.
Marina Denisa Dascal, Adriana Baban, Oana Maria Blaga, Cristian Ioan Meghea   +3 more
doaj   +1 more source

Occupational stress is associated with job performance among pregnant women in Japan: comparison with similar age group of women

BMC Pregnancy and Childbirth, 2022
Background Pregnancy results in physical and psychological changes in women; however, pregnant women hesitate to take a break from work even when they feel the need.
Yasuka Nakamura, Yoko Sumikawa Tsuno, Aya Wada, Keiko Nagasaka, Maiko Kawajiri, Yoko Takeishi, Mikako Yoshida, Toyoko Yoshizawa   +7 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Danish Diabetes Birth Registry 2: a study protocol of a national prospective cohort study to monitor outcomes of pregnancies of women with pre-existing diabetes

BMJ Open
Introduction Despite technological developments and intensified care, pregnancies in women with pre-existing diabetes are still considered high-risk pregnancies.
Peter Damm, Per G Ovesen, Dorte M Jensen, Christina Vinter, Lene Ringholm, Elisabeth R Mathiesen, Jens Fuglsang, Sine Knorr, Ulla Kampmann, Tine D Clausen, Henrik Støvring, Allan Kofoed-Enevoldsen, Jori Aalders, Martin Overgaard, Ulla Bjerre-Christensen, Lise Lotte T Andersen, Jeannet Lauenborg, Trine T Christensen, Anne Sørensen   +18 more
doaj   +1 more source