Results 41 to 50 of about 4,926,663 (261)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women [PDF]

, 2002
A double-blind, placebo, controlled trial was conducted in Banyudono subdistrict, Boyolali regency, Central Java province, Indonesia. The aim of the study was to determine whether adding low-dosage vitamin A and riboflavin can enhance the effect of ...
Suprapto, Bambang, Widardo,, Suhanantyo,
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Lifestyle interventions for overweight and obese pregnant women to improve pregnancy outcome: systematic review and meta-analysis [PDF]

, 2012
BACKGROUND: Overweight and obesity pose a big challenge to pregnancy as they are associated with adverse maternal and perinatal outcome. Evidence of lifestyle intervention resulting in improved pregnancy outcome is conflicting.
Croker, H, Varma, Rajesh, Oteng-Ntim, Eugene, Poston, Lucilla, Helen Croker, Poston, L, Doyle, P, Lucilla Poston, Rajesh Varma, Oteng-Ntim, E, Varma, R, Croker, Helen, Doyle, Pat, Eugene Oteng-Ntim, Pat Doyle, Poston, Lucilla; id_orcid   +15 more
core   +2 more sources

Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy

Clinical Epigenetics
Background Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation.
Line Hjort, Sandra Stokholm Bredgaard, Eleonora Manitta, Irene Marques, Anja Elaine Sørensen, David Martino, Louise Groth Grunnet, Louise Kelstrup, Azadeh Houshmand-Oeregaard, Tine Dalsgaard Clausen, Elisabeth Reinhardt Mathiesen, Sjurdur Frodi Olsen, Richard Saffery, Romain Barrès, Peter Damm, Allan Arthur Vaag, Louise Torp Dalgaard   +16 more
doaj   +1 more source

The association between exposure to polycyclic aromatic hydrocarbons and the risk of premature rupture of membranes

Ecotoxicology and Environmental Safety
Background: Premature rupture of membranes (PROM) remains a significant clinical challenge. It has substantial socioeconomic impacts. Despite the known toxicity of polycyclic aromatic hydrocarbons (PAH), there is limited epidemiological evidence on their
Kui Xie, Haixia Tian, Xinyi Xiao, Linfei Wu, Cheng Chen, Shimin Xiong, Lulu Dai, Xingyan Liu, Rong Zeng, Yan Xie, Yijun Liu, Xubo Shen, Zuqiang Wu, Yuanzhong Zhou   +13 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Prevention and management of excessive gestational weight gain: a survey of overweight and obese pregnant women [PDF]

, 2013
Background - Excessive gestational weight gain is associated with adverse infant, childhood and maternal outcomes and research to develop interventions to address this issue is ongoing. The views of women on gestational weight gain and the resources they
A Gibson, C R Hankey, Leslie, W.S., Hankey, C.R., W S Leslie, Gibson, A.   +5 more
core   +2 more sources

SEXUALITY EXPERIENCE IN PREGNANT WOMAN AT PONDOK AREN TANGERANG HEALTH CENTER

Jurnal Ners, 2017
Introduction: Pregnancy is an important event in women life. Various physical and psychological changes may affect pregnant women, particularly on sexuality.
Vike Dwi Hapsari, Sari Sudarmiati
doaj   +1 more source