Results 31 to 40 of about 2,212,500 (210)

Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos [PDF]

, 2015
During mouse preimplantation development, major changes in cell fate are accompanied by extensive alterations of gene expression programs. Embryos first transition from a maternal to zygotic program and subsequently specify the pluripotent and the ...
Peters, Antoine H. F. M., Liu, Zichuan, Nestorov, Peter, Hotz, Hans-Rudolf   +3 more
core   +1 more source

Pre-implantation genetic diagnosis and pre-implantation genetic screening: two years experience at a single center [PDF]

Obstetrics & Gynecology Science, 2018
ObjectiveIndications for preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles and clinical outcomes were evaluated at CHA Gangnam Medical Center.MethodsThis is retrospective cohort study.
Se Yeon Won, Hannah Kim, Woo Sik Lee, Ji Won Kim, Sung Han Shim   +4 more
doaj   +1 more source

Endometrial thickness and early pregnancy complications after frozen-thawed embryo transfers

Frontiers in Endocrinology, 2023
BackgroundThe relationship between endometrial thickness and pregnancy safety after in vitro fertilization treatment is an important topic that should provoke attention.
Lin Song, Lin Song, Lin Song, Lin Song, Zhiqin Bu, Zhiqin Bu, Zhiqin Bu, Zhiqin Bu, Yingpu Sun, Yingpu Sun, Yingpu Sun, Yingpu Sun   +11 more
doaj   +1 more source

The embryo as moral work object: PGD/IVF staff views and experiences [PDF]

, 2008
Copyright @ 2008 the authors. This article is available in accordance with the Creative Commons Deed, Attribution 2.5, see http://creativecommons.org/licenses/by-nc-nd/2.5/deed.en_CA.We report on one aspect of a study that explored the views and ...
Williams, C, Kathryn Ehrich (16049615), Ehrich, K, Clare Williams (14068554), Farsides, B, Bobbie Farsides (4461928)   +5 more
core   +1 more source

Preimplantation diagnosis for neurofibromatosis

Reproductive BioMedicine Online, 2002
Preimplantation genetic diagnosis (PGD) has recently been performed for inherited cancer predisposition determined by p53 tumour suppressor gene mutations, suggesting the usefulness of PGD for late onset disorders with genetic predisposition, including those caused by the germline mutations of other tumour suppressor genes.
Yury, Verlinsky, Svetlana, Rechitsky, Oleg, Verlinsky, Anna, Chistokhina, Tatyana, Sharapova, Christina, Masciangelo, Michael, Levy, Brian, Kaplan, Kevin, Lederer, Anver, Kuliev   +9 more
openaire   +2 more sources

Laser microdissection as a new approach to prefertilization genetic diagnosis [PDF]

, 2000
The genetic status of oocytes can be determined by polar body (PB) analysis. Following PB extraction, a genetic evaluation is performed. As each PB contains the complementary genetic material of the oocyte, PB analysis reveals information about its ...
Schütze, Karin, Buchholz, Tina, Clement-Sengewald, Annette   +2 more
core   +1 more source

Preimplantation diagnosis for immunodeficiencies

Reproductive BioMedicine Online, 2007
Preimplantation genetic diagnosis (PGD) has become an established procedure for the detection of single gene disorders, and has recently been performed together with human leukocyte antigen (HLA) typing for couples with children affected by genetic disorders that require HLA-identical stem cell transplantation therapy. For these couples, PGD can ensure
Yury, Verlinsky, Svetlana, Rechitsky, Tatyana, Sharapova, Katya, Laziuk, Irina, Barsky, Oleg, Verlinsky, Ilan, Tur-Kaspa, Anver, Kuliev   +7 more
openaire   +2 more sources

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Creating a life to save a life? Reflections on the conception of 'saviour siblings' [PDF]

, 2005
The term “saviour siblings” refers to children whose conception is – at least partially – motivated by the desire of their parents to secure human stem cells to provide treatment for an existing child with a life-threatening illness. It has comparatively
Blyth, Eric
core   +4 more sources

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source