Results 91 to 100 of about 449,800 (228)

Follow‐Up of Left‐Ventricular Assist Device Patients With Telemonitoring: A National Retrospective Multicentric Study on the Satelia LVAD Web Application

Artificial Organs, EarlyView.
We evaluated the usefulness of remote monitoring for advanced heart failure patients using left‐ventricular assist devices (LVADs) in France. A national, retrospective study on a web application (Satelia) at nine locations was conducted. Specialized remote monitoring could facilitate LVAD follow‐ups and improve outcomes.
Clément Delmas, Anne‐Sophie Simoni, Céline Goeminne, Aude Boignard, Anne‐Céline Martin, Fabrice Vanhuyse, Erwan Flecher, Catherine Nafeh‐Bizet, Romain Itier, Nicolas Pages, Sophie Nisse‐Durgeat, Pascal Battistella, Karine Nubret‐le‐Coniat   +12 more
wiley   +1 more source

Expanding the horizons of embryo screening: performance and case studies of preimplantation genetic testing via whole genome sequencing

Academia Molecular Biology and Genomics
Conventional preimplantation genetic testing for aneuploidy (PGT-A) and for monogenic disorders (PGT-M) is very limited in scope. These methods typically assess chromosomal ploidy or target only one or two specific variants carried by the ...
Benjamin Podgursky, Maria Katz, Shenglai Li, Thomas Giardina, Becca Girod, Dhruva Chandramohan, Qinnan Zhang, Michael Feinman, Barry Behr, Jerry Lanchbury, Noor Siddiqui, Funda Suer, Yuntao Xia   +12 more
doaj   +1 more source

Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? [PDF]

, 2023
Yulin Du, Yichun Guan, Na Li, Congxing Shi, Yongjie Zhang, Bingnan Ren, Jing Liu, Hua Lou   +7 more
openalex   +1 more source

Exploring Repro‐Timing Harm and Benefit

Bioethics, EarlyView.
ABSTRACT It is plausible that time of birth affects one's prospects for wellbeing. Being born during a war or recession might have a negative impact on early life and lifetime wellbeing. In natural reproduction, delaying conception does not result in the same child being born later, but rather a different child altogether; therefore, prospective ...
Davide Battisti, Gary David O'Brien
wiley   +1 more source

Evaluating the Clinical Utility of Genomic Sequencing After Perinatal Death

Clinical Genetics, EarlyView.
Genomic sequencing after perinatal death is shown to provide meaningful improvements in counselling, recurrence risk estimation, and family planning—even when a genetic diagnosis is not found. ABSTRACT Following termination of pregnancy for fetal anomaly or unexplained perinatal death (PND), clinical geneticists advise on possible genetic causes and ...
Camille M. Schubert, Matilda R. Jackson, Christopher P. Barnett, Hamish S. Scott, Thomas Sullivan, Stephen Goodall, Tracy Merlin, the Genomic Autopsy Study Research Network, Abhi Kulkarni, Adrian Charles, Alan Ma, Amanda Engel, Anand Vasudevan, Andrew Paul Fennell, Anita Gorrie, Anna Le Fevre, Annabelle Enriquez, Ari Horton, Arjan Bouman, Benjamin Kamien, Bethany Wadling, Bhavya Vora, Bruce Hopper, Cathryn Poulton, Christopher Richmond, Clara W.T. Chung, David J Amor, Di Milnes, Krzesinski Emma, Erica Brown, Fiona Cunningham, Gargi Pathak, George McGillivray, Giorgina Maxwell, Helen Curd, Himanshu Goel, Hugh McCarthy, Jan Liebelt, Janene Davies, Jarrad Dearman, Jason R Pinner, Jaye Richardson, Jennie Slee, Jennifer Rigby, Joanna Perry‐Keene, Jonathan Rodgers, Kaitlin McGinnis, Karin Kassahn, Kate Riley, Kerrie Smyth, Krithika Murali, Kunal Verma, Kushani Jayasinghe, Lara Fitzgerald, Laura Barth, Laura St Clair, Lesley McGregor, Lisa Smith, Lisa Worgan, Lucas De Jong, Lucy Kevin, Lyndal Douglas, Mahalia SB Frank, Margit Shah, Marni Russell, Mary‐Clare Sherlock, Mary‐Louise Freckman, Mathew Wallis, Matthew F Hunter, Matthew Regan, Megan Higgins, Michael Fahey, Michelle Ward, Minmin Li, Miranda Lewit‐Mendes, Molly Krause, Nicholas Pachter, Nikki Gelfand, Noelia Nunez Martinez, Peer Arts, Prue Dunstan, Rachel Pope‐Couston, Renae Parker, Renuka Sekar, Richard Lin, Ron Fleischer, Sachini Poogoda, Sarah A Sandaradura, Shannon LeBlanc, Sheridan O’Donnell, Shuxiang Goh, Sinead O’Sullivan, Stephanie Badman, Sulekha Rajagopalan, Suzanna EL Temple, Suzanne Sallevelt, Tahlee Minto, Tanya Lam, Tara Darmody, Tenielle Davis, Thuong Ha, Tiffany Foo, Yael Prawer   +102 more
wiley   +1 more source

Biochemical Testing Promotes Interpretation of Variants of Uncertain Significance in Prenatal Genetic Disease Testing in Four Organic Acidurias

Clinical Genetics, EarlyView.
This review demonstrates how amniotic fluid biochemical testing provides critical phenotypic evidence (ACMG PP4) for reclassifying variants of uncertain significance (VUS) in prenatal organic acidurias. Integrating metabolite analysis with genetic testing enhances diagnostic accuracy and enables informed clinical decisions for affected families ...
Kaili Yin, Qingwei Qi
wiley   +1 more source

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

Cell Proliferation, EarlyView.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing, Siqi Yang, Yuchao Liang, Pengwei Hu, Bingjie Dai, Hanshuang Li, Yongqiang Xing, Yongchun Zuo   +7 more
wiley   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

Haplotyping by linked-read sequencing (HLRS) of the genetic disease carriers for preimplantation genetic testing without a proband or relatives [PDF]

, 2020
Li Q, Yan Mao, Shaoying Li, Hongzi Du, Wenzhi He, Jianchun He, Lingyin Kong, Jun Zhang, Bo Liang, Jianqiao Liu   +9 more
openalex   +1 more source

Effects of Gender of Reciprocal Chromosomal Translocation on Blastocyst Formation and Pregnancy Outcome in Preimplantation Genetic Testing [PDF]

, 2021
Hui Song, Hao Shi, En-tong Yang, Zhiqin Bu, Ziqi Jin, Mingzhu Huo, Yile Zhang   +6 more
openalex   +1 more source