Results 81 to 90 of about 4,572,851 (176)

Preimplantation Genetic Testing

Obstetrics & Gynecology, 2020
ABSTRACT: Preimplantation genetic testing comprises a group of genetic assays used to evaluate embryos before transfer to the uterus. Preimplantation genetic testing-monogenic is targeted to single gene disorders, and preimplantation genetic testing-aneuploidy is a broader test that screens for aneuploidy in all chromosomes, including
openaire   +4 more sources

Shaping Future Children, Sex Selection, and “Normal” Human Capacities

Bioethics, EarlyView.
ABSTRACT If we think that parents have an obligation to have a healthy child then we need to know what counts as healthy, when male and female children are born with very different capacities. If we give up on the idea that our obligations to use technologies of genetic selection are discharged once we try to secure the birth of a healthy child, as ...
Robert Sparrow
wiley   +1 more source

Prevention of Leber congenital amaurosis through preimplantation genetic diagnosis

, 2018
© 2018 American Association for Pediatric Ophthalmology and Strabismus Preimplantation genetic diagnosis can allow a family with a hereditary genetic mutation to conceive a disease-free child.
Fox, J. E., Bristow, S. L., Sylvia R. Kodsi, Kodsi, S. R., Joyce E. Fox, Sara L. Bristow, Avner Hershlag, Hershlag, A.   +7 more
core   +1 more source

Preimplantation Genetic Testing in the 21st Century: Uncharted Territory

Clinical Medicine Insights: Reproductive Health, 2013
The past hundred years have given birth to arguably the most profound changes in society, medicine, and technology the world has ever witnessed. Genetics is one such field that has enjoyed a meteoric rise during this time.
Paul R. Brezina MD, MBA
doaj   +2 more sources

Derivation of Mouse Dome‐Shaped Trophoblast Stem Cells With Low Heterogeneity From Blastocysts

Cell Proliferation, EarlyView.
Here, Liu et al. report the generation of mouse dome‐shaped trophoblast stem cells (dTSCs) with low heterogeneity and autonomous differentiation potential. dTSCs robustly generate all trophoblast lineages in vitro and contribute to the placenta in vivo, providing a refined model for studying trophoblast development and related disorders.
Minli Liu, Shaofang Ren, Xinyu Xia, Guanlin Lu, Haojie Yang, Yi Zheng, Jiexiang Zhao, Xiao‐Yang Zhao, Mei Wang   +8 more
wiley   +1 more source

Technological Advances in Molecular Diagnostic Methods for Hereditary Diseases in Preconception and Prenatal Settings

Current Issues in Molecular Biology
Precision prevention and control of genetic diseases represent a major public health challenge. This paper provides a structured narrative review of advances in molecular diagnostic technologies across the preconception, preimplantation, and prenatal ...
Deyuan Kong, Jianing Zhao, Haichang Diao, Shuyao Qiu, Yuanyuan Peng, Tingting Liu   +5 more
doaj   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Preimplantation Genetic Screening: A Practical Guide

, 2013
The past several decades have seen tremendous advances in the field of medical genetics. The application of genetic technologies to the field of reproductive medicine has ushered in a new era of medicine that is likely to greatly expand in the coming ...
William H. Kutteh, Paul R. Brezina, Raymond W. Ke   +2 more
core   +1 more source

Genetic testing in Marfan syndrome [PDF]

, 2016
Genetic testing is aiding rapid diagnosis of Marfan syndrome as a basis for management of eye, heart and skeletal disease. The affected patient's mutation can be used as a basis for prenatal or postnatal diagnosis of offspring.
Child, AH, Aragon-Martin, JA, Sage, K
core   +1 more source

Company‐Sponsored Fertility Benefits: A Gift‐Exchange and Contextual Intersectionality Informed “FAiRE” Framework Guiding Design and Implementation

Gender, Work &Organization, EarlyView.
ABSTRACT Managing the work‐fertility interface is a major challenge for organizations when implementing fertility policies. These policies cover a broad spectrum of areas including clinical treatments, preservation and storage of eggs and sperm, preimplantation and diagnostics, and non‐clinical family‐building assistance. They also differ from standard
Clíodhna MacKenzie, Thomas Garavan, Elaine O'Brien   +2 more
wiley   +1 more source