Results 71 to 80 of about 449,800 (228)

Preimplantation Genetic Testing for Kidney Disease-Related Genes: A Laboratory’s Experience [PDF]

, 2021
J Chaperon, Nina Wemmer, Trudy McKanna, Dinah Clark, Maggie Westemeyer, Philippe Gauthier, Yan Bai, Jessica M. Coleman   +7 more
openalex   +1 more source

Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases

Circulation Genomic and Precision Medicine
BACKGROUND: Preimplantation genetic testing (PGT) is a reproductive technology that selects embryos without (familial) genetic variants. PGT has been applied in inherited cardiac disease and is included in the latest American Heart Association/American ...
J. Verdonschot, D. Hellebrekers, Vanessa P. M. van Empel, M. Heijligers, Sonja de Munnik, E. Coonen, J. Dreesen, A. van den Wijngaard, Han G. Brunner, M. Zamani Esteki, S. Heymans, C. D. de Die-Smulders, Aimee D C Paulussen   +12 more
semanticscholar   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Preimplantation Genetic Testing in the 21st Century: Uncharted Territory

Clinical Medicine Insights: Reproductive Health, 2013
The past hundred years have given birth to arguably the most profound changes in society, medicine, and technology the world has ever witnessed. Genetics is one such field that has enjoyed a meteoric rise during this time.
Paul R. Brezina MD, MBA
doaj   +2 more sources

Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)

Journal of Assisted Reproduction and Genetics
Preimplantation Genetic Testing (PGT) has attracted considerable ethical, legal, and social scrutiny, but academic debate often fails to reflect clinical realities.
Ido Alon, Ilona Bussod, V. Ravitsky
semanticscholar   +1 more source

Prenatal Exome Sequencing Analysis in Fetuses With Structural Anomalies: A Multicenter Prospective Cohort Study With Practical Implications

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the diagnostic value of prenatal exome sequencing (ES) integrated with copy number variant (CNV) and single nucleotide variant (SNV) analysis (ES‐CNV/SNV) in fetuses with structural anomalies following negative chromosomal microarray analysis (CMA) and karyotyping, and to delineate the practical challenges encountered ...
Yulin Jiang, Haibo Li, Xiangyu Zhu, Liangpu Xu, Ying Chang, Fengqun Dong, Jianping Xiao, Jian Gao, Minyue Dong, Ying Peng, Hua Jin, Ting Wang, Xiaoxiao Xie, Lin Zhang, Hongmei Zhuang, Na Hao, Xiya Zhou, Hongna Wang, Ying You, Kun Ma, Rui Xiao, Qingwei Qi   +21 more
wiley   +1 more source

Fertility Preservation as an Option for Women with Genetic Disorders: Insights from a SWOT Analysis on Elective Oocyte Freezing and Preimplantation Genetic Testing

Life, 2023
This paper uses a SWOT (strengths, weaknesses, opportunities, and threats) analysis to overview the option of fertility preservation in women with genetic diseases, who would later use preimplantation genetic testing for monogenic disorders, in order to ...
Greta Chiara Cermisoni, Valerio Pisaturo, Valeria Stella Vanni, Sabrina Minetto, Luca Pagliardini, Rossella Masciangelo, Massimo Candiani, Enrico Papaleo, Alessandra Alteri   +8 more
doaj   +1 more source

Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy

Frontiers in Endocrinology, 2023
Objective The purpose of this study was to evaluate the influence of abnormal semen parameters on embryo aneuploidy based on single nucleotide polymorphism microarray (SNP array).
Hongyi Yang, Yan Liu, W. Niu, Zilan Yang, Yangyu Wang, Haixia Jin, Gang Li   +6 more
semanticscholar   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

P-718 Preimplantation genetic testing in Belgium: recommendations for the genetic centres [PDF]

, 2023
Elia Fernandez Gallardo, Martine De Rycke, Veerle Berckmoes, Pieter Verdyck, Eftychia Dimitriadou, Olga Tšuiko, Ellen Denayer, Machteld Baetens, Sandra Janssens, Sofie Symoens, Sigri Beckers, Bettina Blaumeiser, Bruno Pichon, Eric Gonzalez-Merino, Jean‐Marie Billard   +14 more
openalex   +1 more source