Results 71 to 80 of about 16,266,038 (328)

Systematic Design of Cathode Air Supply Systems for PEM Fuel Cells

Energies
To increase system efficiency and power density, the cathode air path of Polymer Electrolyte Membrane Fuel Cells (PEM FCs) is supercharged using electrically driven air bearing centrifugal compressors.
Johannes Klütsch, Stefan Pischinger
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Brightest Of Reionizing Galaxies Survey: Design and Preliminary Results

, 2010
We present the first results on the search for very bright (M_AB -21) galaxies at redshift z~8 from the Brightest of Reionizing Galaxies (BoRG) survey. BoRG is a Hubble Space Telescope Wide Field Camera 3 pure-parallel survey that is obtaining images on ...
Bouwens, Bouwens, Bouwens, Bouwens, Capak, Casertano, Chary, Dressel, Finkelstein, Henry, Knapp, Koekemoer, Labbé, Oesch, Oesch, Oesch, Ouchi, Reid, Schlegel, Steidel, Trenti, Trenti, Yan   +22 more
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

High-Luminosity Large Hadron Collider (HL-LHC) : Preliminary Design Report

, 2015
The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up a new energy frontier for exploration in 2010, it has gathered a global user community of about 7,000 scientists working in fundamental particle ...
G. Apollinari, I. B. Alonso, O. Brüning, M. Lamont, L. Rossi   +4 more
semanticscholar   +1 more source

Prague's Emission Fourier Transform Microwave Spectrometer - Design and Preliminary Results [PDF]

, 2013
The design, performance and operation of the high resolution microwave spectrometer are described. The spectrometer is based on the Fabry-Perot resonator supplemented by a pulsed supersonic nozzle for adiabatic cooling of the sample.
Cerny, P., Kabourek, V., Kania, P., Piksa, P., Studecky, T., Urban, S.   +5 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

СОВРЕМЕННОЕ СОСТОЯНИЕ ПЕРВИЧНОГО ПРОЕКТИРОВАНИЯ НА ПРИМЕРЕ ЦЕНТРОБЕЖНЫХ КОМПРЕССОРОВ ТУРБОДЕТАНДЕРНЫХ АГРЕГАТОВ

Cifra: Машиностроение
Цифровизация технологических процессов привела к тому, что заказчики турбодетандерных агрегатов с центробежными компрессорами требуют обеспечить расчет газодинамических характеристик компрессоров и требования технического задания к потребляемой мощности ...
Рекстин А.Ф., Галеркин Ю.Б., Бабиченко И.А., Михайлов А.А., Соколов К.К., Семеновский В.Б.   +5 more
doaj   +1 more source