Results 111 to 120 of about 214,960 (327)
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. [PDF]
, 2014 The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown.
Chen, Robert Y +8 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Regional brain aging: premature aging of the domain general system predicts aphasia severity
Communications BiologyPremature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual.
Natalie Busby +12 more
doaj +1 more source
Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System
International Journal of Nephrology, 2018 The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates.
Makoto Kuro-o
doaj +1 more source
Premature Aging and Premature Age-Related Comorbidities in HIV-Infected Patients: Facts and Hypotheses [PDF]
Clinical Infectious Diseases, 2011 In the present issue of Clinical Infectious Diseases, Guaraldi et al [ 5 ] analyze the important cohort of patients followed up at the Metabolic Clinic of Modena (Italy) who underwent a complete set of clinical, biological, and imaging investigations, allowing investigation of comorbidities.
openaire +3 more sources
Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]
, 2015 Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley +10 more
core +3 more sources
Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis
Advanced Healthcare Materials, EarlyView.An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back +3 more
wiley +1 more source
Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]
, 2013 Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara +6 more
core +2 more sources
Advanced Materials, EarlyView.Advancing gas‐phase electrolysis toward industrial‐scale applications requires not only the development of advanced electrocatalysts but also the design of the electrodes to optimize gas‐electrode‐electrolyte interfaces and facilitate efficient mass transport, thereby reinforcing gas win the electrons to promote reaction kinetics and suppress side ...
Guoliang Chen +8 more
wiley +1 more source
The Pan African Medical Journal, 2017 INTRODUCTION: this study has been performed to determine the influence of rotating shift work on physical working capacity of Tunisian nurses and to design recommendations to managers so that they implement effective preventive measures.
Irtyah Merchaoui +6 more
doaj +1 more source