Results 171 to 180 of about 214,960 (327)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Infant outcomes at 2 years of age with a short latency period after preterm premature rupture of membranes in a prospective regional cohort study (Dominos study) [PDF]

, 2005
Jean‐Charles Pasquier, Emmanuel Bujold, Jean‐Charles Picaud, Muriel Rabilloud, Olivier Claris, René Écochard, Stéphanie Moret, Georges Mellier   +7 more
openalex   +1 more source

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

Estimates of the cost and length of stay changes that can be attributed to one-week increases in gestational age for premature infants [PDF]

, 2006
Ciaran S. Phibbs, Susan Schmitt
openalex   +1 more source

Missing checkpoints in premature aging

Nature Aging, 2023
Huijing Xue, Kan Cao
openaire   +2 more sources

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

The Early Treatment for Retinopathy Of Prematurity Study: structural findings at age 2 years [PDF]

, 2006
William V. Good, Robert J. Hardy, Velma Dobson, Earl A. Palmer, Dale L. Phelps, Michelle Quintos, Betty Tung, Ashima Madan, M. Bethany Ball, Patricia N. Hartsell, Dottie Inguillo, Michael W. Gaynon, Deborah Alcorn, Donna Ornitz, Judith Gancasz, D Durand, Terri A. Slagle, Gordon L. Smith, Michael J. Shapiro, Yesenia García, Maria Genio, Jeffrey N. Bloom, Lawrence M. Kaufman, Wico Wai-Kwan Lai, Marilyn Miller, Daniel E. Neely, Elizabeth Hynes, James A. Lemons, David A. Plager, Naval Sondhi, Derek T. Sprunger, Paul J. Rychwalski, Greg K. Whittington, Peggy H. Fishman, Robert Gordon, Deborah S. Neff, Douglas B. Babel, James G. Diamond, William L. Gill, Scott M. Steidl, Kelly A. Hutcheson, Kevin L. Powdrill, Eric Jones, Mark W. Preslan, Michael X. Repka, Jennifer Shepard, Pamela K. Donahue, Susan W. Aucott, Mary Louise Z. Collins, Maureen Gilmore, James T. Handa, Cynthia H. Cole, Deborah K. VanderVeen, Terri Mansfield, Brenda L. MacKinnon, Anthony J. Fraioli, O'ine McCabe, Robert B. Peterson, David G. Hunter, Sarah MacKinnon, Rhiannon Johnson, Mariette Tyedmers, John P. Baker, Krist Cumming, Pat Manatrey, Antonio Capone, Edward R O’Malley, Rajesh C. Rao, John D. Roarty, Michael T. Trese, George A. Williams, Stephen P. Christiansen, Sally Cook, Ann M. Holleschau, C. Gail Summers, Bradley V. Davitt, Linda Breuer, Oscar Cruz, William Keenan, G. J. Mantych, Gregg T. Lueder, Sharon F. Freedman, David K. Wallace, Lori Hutchins Parkman, Sarah K. Jones, Laura B. Enyedi, James D. Reynolds, Kristine Ziemann, George Albert, Steven Awner, Rita M. Ryan, Pamela Ann Weber, Marc E. Horowitz, Cherylene Behrendt, Natalie Dweck, Richard Koty, Edmund F. LaGamma, John T. Flynn, Thomas C. M. Lee, Osode Coki   +99 more
openalex   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging. [PDF]

Bone Res
Yılmaz D, Marques FC, Gregorio L, Schlatter J, Gehre C, Pararajasingam T, Qiu W, Mathavan N, Qin XH, Wehrle E, Kuhn GA, Müller R.   +11 more
europepmc   +2 more sources