Results 201 to 210 of about 214,960 (327)

Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening

Advanced Science, EarlyView.
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu, Yu Liu, Junheng Zhang, Shuang Yang, Tianming Li, Haiqian Huang, Qian Liu, Hengliang Wang, Li Cao, Zhenghua An, Min Li, Hua Wang   +11 more
wiley   +1 more source

The influence of amino-acid supplementation, gestational age and time on thyroxine levels in premature neonates [PDF]

, 2008
Amy S. Kelleher, Reese H. Clark, M Steinbach, Donald H. Chace, Alan R. Spitzer   +4 more
openalex   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Human Genetic Disorders Associated with Genome Instability, Premature Aging and Cancer Predisposition [PDF]

, 2008
Razmik Mirzayans, David Murray
openalex   +1 more source

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity

, 2004
Graham E. Quinn, Velma Dobson, Saroj Saigal, Dale L. Phelps, Robert J. Hardy, Betty Tung, C. Gail Summers, Earl A. Palmer   +7 more
openalex   +1 more source

Innovative Design of PEI‐Modified AMO‐Layered Double Hydroxide for Efficient and Stable Direct Air Capture of CO2

Advanced Science, EarlyView.
An uncalcined, hydroxyl‐rich MgAl layered double hydroxide, synthesized via low‐energy aqueous miscible organic solvent treatment, enables mesopore‐engineered polyethyleneimine anchoring for direct air capture (DAC). The exfoliated structure exposes abundant hydroxyls that stabilize amines via hydrogen bonding, effectively suppressing oxidative ...
Meng Zhao, Liang Huang, Yanshan Gao, Ziling Wang, Xuancan Zhu, Qiang Wang, Dermot O'Hare   +6 more
wiley   +1 more source

rDNA Copy Number Variation and Methylation During Normal and Premature Aging. [PDF]

Aging Cell
Geisen ABC, Santana Acevedo N, Oshima J, Dittrich M, Potabattula R, Haaf T.   +5 more
europepmc   +1 more source

Premature aging in childhood cancer survivors. [PDF]

Oncol Lett, 2023
Kruseova J, Zichova A, Eckschlager T.
europepmc   +1 more source

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice [PDF]

, 2009
Daniel Edgar, Irina G. Shabalina, Yolanda Cámara, Anna Wredenberg, Maria Antonietta Calvaruso, Leo Nijtmans, Jan Nedergaard, Barbara Cannon, Nils‐Göran Larsson, Aleksandra Trifunović   +9 more
openalex   +1 more source