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Cellular senescence and premature aging in Down Syndrome

Mechanisms of Ageing and Development, 2023
Down syndrome (DS) is a genetic disorder caused by an extra copy of chromosome 21, resulting in cognitive impairment, physical abnormalities, and an increased risk of age-related co-morbidities.
Julio Aguado, Ernst J Wolvetang
exaly   +2 more sources

Syndromes of Premature Aging

Dermatologic Clinics, 1987
The classic premature aging syndromes are rare disorders, all of which clinically differ a great deal from the normal aging process. None is well understood at the biochemical level, and no specific treatment exists for any of these syndromes. Genetic counseling, preventive measures in some instances, and symptomatic treatment are available.
S, Beauregard, B A, Gilchrest
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The premature aging syndromes

Clinics in Dermatology, 1996
T he premature aging syndromes are rare disorders that mimic senescence. Interest in these syndromes has been great, in part because a more complete understanding of the pathophysiology of these syndromes may provide enhanced insight into the natural aging process.
K, Pesce, M J, Rothe
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Premature Aging in Fibromyalgia

Current Aging Science, 2015
Chronic pain is highly prevalent in older adults, and until recently, was considered to be common but relatively "benign." Mounting evidence, however, suggests that some of the 116 million US adults who suffer from chronic pain are also at an increased risk for developing age-related diseases prematurely, suffering earlier cognitive and physical ...
Afton L, Hassett   +2 more
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Premature Aging and Alcoholism

International Journal of the Addictions, 1982
The proposition is frequently put forth in the literature dealing with alcohol abuse that the process which underlies the cognitive impairment found in chronic alcoholics is premature aging of the central nervous system (Fitzhugh et al., 1965; Kish and Cheney, 1969; Goldstein and Shelly, 1971; Smith et al., 1971; Jones and Parsons, 1972; Kleinknecht ...
W R, Leber, O A, Parsons
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SIRT1 regulates trophoblast senescence in premature placental aging in preeclampsia.

Placenta, 2022
INTRODUCTION Premature placental aging is implicated in a number of complications of pregnancy including preeclampsia. A placenta knockout mouse model has shown a relationship between SIRT1, aging and placental dysfunction.
YuJia Wang   +7 more
semanticscholar   +1 more source

Premature aging in uremia

Molecular and Cellular Biochemistry, 2006
Guanidinosuccinic acid is an aberrant metabolite isolated 40 years ago in the blood and urine of uremic subjects and a suspect in the toxicity associated with renal failure. It plays a minor role in the bleeding diathesis of uremia, contributes to the methyl group deficiency of dialysis patients, and is a factor in the premature atherosclerosis of end ...
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Etiological Factors and Premature Aging

JAMA, 1962
AGING IS an interesting subject which is receiving increasing attention in many fields. There is an ever-enlarging body of information which indicates that many of the phenomena which were previously regarded as "natural" processes resulting from old age are actually due to specific disease processes.
J M, KNOX, E G, COCKERELL, R G, FREEMAN
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