Results 111 to 120 of about 2,175,601 (208)

Chromosomal abnormalities in women with premature ovarian failure.

, 2010
Premature ovarian failure is a complex disorder that results in the early loss of ovarian function; however this disease must be separated from early menopause because these patients can sporadically ovulate and in literature are described pregnancies ...
Ruggiero M, GENAZZANI, ANDREA, ARTINI, PAOLO GIOVANNI, Cela V, Valentino V, Uccelli A, Papini F   +6 more
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T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Clinical Efficacy and Experimental Research Progress on Traditional Chinese Medicine Moxibustion Therapy in Ovarian Injury

Chinese Medicine and Natural Products
This review summarizes the clinical efficacy and experimental research of traditional Chinese medicine (TCM) moxibustion in the intervention of ovarian injury.
Houpeng Wang, Ning Zhang, Liping Zheng, Liaoliao Hu   +3 more
doaj   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Uterine prolapse in a young nulligravida with scleroderma and premature ovarian failure

, 2005
We report a case of pelvic organ prolapse quantification (POPQ) stage III uterine prolapse in a 25-year-old nulligravida. Premature ovarian failure was diagnosed after 1 year of amenorrhea.
Doger, E, Caliskan, E, Ercin, C, Vural, B   +3 more
core   +1 more source

The PCOS‐to‐PMOS shift in the broader history of nomenclature changes and its uncertain impact on clinical practice

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Proposed renaming of polycystic ovary syndrome (PCOS) to polyendocrine metabolic ovarian syndrome (PMOS) aims to broaden multidisciplinary care. However, it may obscure reproductive manifestations and introduce phenotypic ascertainment bias. Historical examples of nomenclature changes suggest that clinical benefits depend heavily on diagnostic ...
Elina Aleksejeva‐Zagura, Piotr Laudański, Ganesh Acharya, Andres Salumets   +3 more
wiley   +1 more source

The leukaemia in pregnancy study, a national multicentre retrospective study of pregnancy outcomes in women with concurrent or historic diagnoses of acute leukaemia

British Journal of Haematology, EarlyView.
Summary The leukaemia in pregnancy study was a multicentre retrospective study of pregnancy outcomes of women with concurrent (CAL) or previous (PAL) acute leukaemia. Cases were identified from eight hospitals. Of 39 screened cases, 12 CAL and 21 PAL cases were described, with one belonging to both groups.
Lukas Pitel, Matthew Northgraves, Judith Cohen, Chao Huang, John Turgoose, Simone Green, Steve Knapper, Gail Jones, Sarah Essex, Julie Kenny, Mhairi Copland, Panagiotis D. Kottaridis, Anjum Khan, Sahra Ali, David Allsup   +14 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Telomeres, telomerase and premature ovarian failure

Zdravniški Vestnik, 2011
Telomeres are specialized structures at the ends of chromosomes, consisting of six repeated nucleotides in TTAGGG sequence. Genome stability is partly maintained by the architecture of telomeres and is gradually lost as telomeres progressively shorten ...
Renata Košir Pogačnik, Nina Slabe, Helena Meden Vrtovec   +2 more
doaj  

STUDY OF PRIMORDIAL FOLLICLE, CORPORA LUTEA AND Fmr1 mRNA LEVELS FROM OVARIUM OF Fmr1 GENE PREMUTATION MICE [PDF]

, 2010
Background : The FMR1 gene involves in fragile X-associated disorders (FAD), including the fragile X mental retardation syndrome, primary ovarian insufficiency (POI) and Fragile X associated tremor/ataxia syndrome.
Santoso, Santoso
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