Results 131 to 140 of about 2,087,459 (277)

Premature ovarian failure

The Journal of the American Osteopathic Association, 1985
R, Markwood, D, Magyar
openaire   +2 more sources

Impaired endothelial function in young women with premature ovarian failure: Normalization with hormone therapy

, 2004
Normal menopause is associated with vascular endothelial dysfunction, an early stage of atherosclerosis. The effect of premature ovarian failure ( or premature menopause) on endothelial function in young women is unknown.
Kalantaridou, S. N., Naka, K. K., Calis, K. A., Kazakos, N., Kravariti, M., Chrousos, G. P., Papanikolaou, E., Sideris, D. A., Michalis, L. K., Tsatsoulis, A., Paraskevaidis, E. A.   +10 more
core  

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Tanner stages of thelarche in relation to anthropometric and ultrasound predictors in premenarcheal girls

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
We found a close correlation between thelarche and internal genital maturation on pelvic ultrasound, paralleling Tanner breast stages and supporting the concept of correlated external and internal pubertal development. Abstract Introduction Thelarche is often the first sign of puberty initiation in girls.
Andrius Cekuolis, Zivile Sabonyte‐Balsaitiene, Eugenijus Jasiunas, Rytis Marozas, Janina Tutkuviene, Diana Ramasauskaite, Zana Bumbuliene   +6 more
wiley   +1 more source

Ovarian surface epithelium stem cells: oogenesis in vitro?

Zdravniški Vestnik, 2007
Background: The dogma that the total number of follicles and oocytes available for reproduction are determined at birth, and that one follicle and one oocyte are recruited from the existing pool to mature in each menstrual cycle still persists.
Irma Virant-Klun, Primož Rožman, Branko Cvjetičanin, Andrej Vogler, Polona Klemenc, Elvira Maličev, Alojz Ihan, Jasna Šinkovec, Eda Vrtačnik-Bokal, Tomaž Tomaževič, Helena Meden-Vrtovec   +10 more
doaj  

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Impact of diabetes mellitus on the menopausal experience: A scoping review

Diabetic Medicine, EarlyView.
Abstract Aims To identify, appraise and synthesise the current evidence relating to symptoms, experiences, management and impact of menopause on QoL among women with type 1 diabetes (T1DM) or type 2 diabetes (T2DM) and to identify evidence gaps. Methods We conducted a scoping review guided by Arksey and O'Mally's framework by searching CINAHL, MEDLINE,
Rachel Black, Felicity Hasson, Lisa King, Mark Davies, Deborah Muldrew, Paul Slater, Jenny Johnston, Dawn Adams, Rhonda Murphy, George Kernohan, Vivien Coates   +10 more
wiley   +1 more source

Economic Burden of Overweight and Obesity in Sweden: Current Estimates and Future Projections

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Overweight and obesity are major public health challenges and well‐established risk factors for cardiovascular disease, cancer and premature mortality. We estimated the economic burden of overweight and obesity in Sweden in 2023 and projected the future economic burden in 2040 under alternative scenarios of increasing prevalence ...
Adam Fridhammar, Jovanna Dahlgren, Marije Galavazi, Lena Hjelm, Jonatan Dereke, Katarina Steen Carlsson   +5 more
wiley   +1 more source