Results 141 to 150 of about 2,175,601 (208)

Session IIB: Natural Sciences Presentation 3 - The Effects of Human Umbilical Mesenchymal Stem Cells in Treating Premature Ovarian Failure [PDF]

Short lit review of the factors in using human mesenchymal stems cells to treat premature ovarian ...
Proffitt, Lainey
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New‐Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank

International Journal of Cancer, Volume 159, Issue 11, Page 2705-2719, 1 December 2026.
ABSTRACT The prevalence of type 2 diabetes mellitus (T2DM) is rising rapidly in China and is linked to increased cancer risk, but causality remains unclear due to biases. We examined the causal effect of T2DM on cancer risk using bias‐minimizing methods.
Mengying Wang, Owen Tipping, Bowen Liu, Derrick A. Bennett, Baiyong Shen, Siyi Zou, Shulin Zhao, Richard M. Martin, Matthew Sperrin, Andrew G. Renehan   +9 more
wiley   +1 more source

Reproductive Changes in Women with Premature Ovarian Failure

Failure to become pregnant after therapy forces the patient to use assisted reproductive technologies using donor embryos and oocytes, while the effectiveness of in vitro fertilization does not exceed 58%.
Mo‘minjonovna, B. M. (Boboxonova)
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Premature ovarian failure, endothelial dysfunction and estrogen-progestogen replacement

, 2006
Cardiovascular disease, including coronary artery disease, stroke and peripheral vascular disease, is the leading cause of death among women. Vascular endothelial dysfunction is an early marker of atherosclerosis. Women with premature ovarian failure (or
Kalantaridou, SN, Chrousos, GP, Naka, KK, Bechlioulis, A, Michalis, L, Makrigiannakis, A   +5 more
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Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3175-3182, November 2026.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim, Janghan Lee, Seo‐Yeon Kim, Jihoon Kim, Moo Sun Hong   +4 more
wiley   +1 more source

Treatment of autoimmune premature ovarian failure

, 1999
There is no known immunosuppressive therapy for autoimmune premature ovarian failure that has been proven safe and effective by prospective randomized placebo-controlled study.
Patronas, N. J., Kalantaridou, S. N., Braddock, D. T., Nelson, L. M.   +3 more
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Young bodies, aging ovaries: A systematic review and meta‐synthesis of women's perspectives on spontaneous premature ovarian insufficiency

International Journal of Gynecology &Obstetrics, Volume 175, Issue 2, Page 619-630, November 2026.
Abstract Objectives Spontaneous premature ovarian insufficiency (POI) is a condition characterized by the cessation of ovarian function before age 40, unrelated to medical interventions. It affects approximately 3.5% of women worldwide and can result in significant emotional, physical, and social consequences.
Maria Patricia Roman, Shaurya Aggarwal, Stergios K. Doumouchtsis   +2 more
wiley   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, Volume 34, Issue 11, Page 2051-2060, November 2026.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source