Results 161 to 170 of about 2,175,601 (208)
Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics
ChemBioChem, Volume 27, Issue 20, 28 October 2026.This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 19, 15 October 2026.Schematic illustrating that NR4A1‐driven granulosa cell ferroptosis mediates obesity‐related ovarian dysfunction, while metformin‐mediated ovarian protection is achieved via suppression of the PI3K/AKT–NR4A1 ferroptotic signaling cascade. ABSTRACT Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage ...
Huihui Wang +17 more
wiley +1 more source
Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova +3 more
wiley +1 more source
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Acta Obstetricia et Gynecologica Scandinavica, 1973
Abstract. Twenty‐six patients with premature ovarian failure (last menstrual period before the age of 30 years) were evaluated clinically and endocrinologically and, in addition, ovarian biopsies were obtained in 15 out of the 26 patients. Only 1 of the patients revealed a family history of early menopause.
J, Starup, V, Sele
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Abstract. Twenty‐six patients with premature ovarian failure (last menstrual period before the age of 30 years) were evaluated clinically and endocrinologically and, in addition, ovarian biopsies were obtained in 15 out of the 26 patients. Only 1 of the patients revealed a family history of early menopause.
J, Starup, V, Sele
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Obstetrical & Gynecological Survey, 1981
Premature ovarian failure remains a multifactorial syndrome in which genetic, immune, and environmental factors may play a role. The possible etiology and pathophysiology of premature ovarian failure is reviewed. A scheme of the management of premature ovarian failure is illustrated. This allows a logical approach in which the final diagnosis has to be
T, Tulandi, R A, Kinch
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Premature ovarian failure remains a multifactorial syndrome in which genetic, immune, and environmental factors may play a role. The possible etiology and pathophysiology of premature ovarian failure is reviewed. A scheme of the management of premature ovarian failure is illustrated. This allows a logical approach in which the final diagnosis has to be
T, Tulandi, R A, Kinch
openaire +2 more sources
Obstetrics & Gynecology, 2000
Premature ovarian failure is the term usually used to describe women aged younger than 40 years who present with amenorrhea, hypergonadotropinism, and hypoestrogenism. Such women may ovulate and even conceive after the diagnosis is made, so it may be more appropriate to refer to these patients as having "primary ovarian insufficiency," or alternatively,
W. Vegetti +10 more
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Premature ovarian failure is the term usually used to describe women aged younger than 40 years who present with amenorrhea, hypergonadotropinism, and hypoestrogenism. Such women may ovulate and even conceive after the diagnosis is made, so it may be more appropriate to refer to these patients as having "primary ovarian insufficiency," or alternatively,
W. Vegetti +10 more
openaire +5 more sources
Aetiology of Premature Ovarian Failure
Menopause International, 2009Premature ovarian failure (POF) is the occurrence of hypergonadotropic hypoestrogenic amenorrhoea in women under the age of 40 years. POF is idiopathic in 74–90% of cases but can be familial (4–33%) or sporadic. The known causes are: genetic aberrations; autoimmune ovarian damage; iatrogenic following surgery, radiotherapy or chemotherapy ...
Svetlana Vujovic
exaly +3 more sources
Current Opinion in Obstetrics and Gynecology, 1997
The past 2 years have seen progress in our understanding of the process of premature ovarian failure with identification of molecular causes and clarification of the autoimmune targets within the ovary. With the knowledge that most women with premature ovarian failure have ovarian follicles on ultrasonography, we eagerly await the next therapeutic ...
openaire +5 more sources
The past 2 years have seen progress in our understanding of the process of premature ovarian failure with identification of molecular causes and clarification of the autoimmune targets within the ovary. With the knowledge that most women with premature ovarian failure have ovarian follicles on ultrasonography, we eagerly await the next therapeutic ...
openaire +5 more sources
Premature Ovarian Failure: An Update
Fertility and Sterility, 1998To present an overview of potential etiologies, clinical manifestations, and treatment modalities of premature ovarian failure (POF).A search of past and current articles on basic ovarian physiology and POF with use of MEDLINE. Additional information was obtained from an active study section on POF at the National Institutes of Health.
J N Anasti
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Premature ovarian failure: a review
Climacteric, 2007To present an updated review on the etiology, consequences and management of premature ovarian failure.A search of the English language literature using the Cochrane Library database and Medline 1966-2006, with a hand search of the references.Premature ovarian failure is defined as the occurrence of amenorrhea, hypergonadotropinemia and estrogen ...
T A, Nippita, R J, Baber
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