The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang +15 more
wiley +1 more source
Mechanism of platelet-rich plasma in improving cyclophosphamide-induced premature ovarian failure in rats. [PDF]
Stem Cell Res TherZhao T +6 more
europepmc +1 more source
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, Volume 13, Issue 31, 4 June 2026.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
The role of autoimmunity in premature ovarian failure.
, 2015 Mahbod Ebrahimi, Firouzeh Akbari Asbagh
openalex +1 more source
Establishment of an optimized chemotherapy-induced mouse model for premature ovarian failure: protocol and findings. [PDF]
Aging (Albany NY)Yavari N +5 more
europepmc +1 more source
Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Sex differences are increasingly recognized as central to the biology of Alzheimer's disease (AD), yet the mechanisms through which they shape brain metabolism and disease vulnerability remain incompletely understood. Brain glucose hypometabolism is a core hallmark of AD and emerges decades before clinical decline, but accumulating evidence ...
Marjan Ramezan +4 more
wiley +1 more source
Impact of Allostatic Load on Overall Survival in Patients With Endometrial Cancer
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Introduction Endometrial cancer (EC) mortality is rising, with increasing rates of advanced disease and high‐risk histologic subtypes. Allostatic load (AL), a biomarker of cumulative physiologic stress, has been linked to cancer‐associated outcomes.
Nikita Sinha +5 more
wiley +1 more source
“My Family Health Portrait”: nursing application of a web-based tool to evaluate women with primary ovarian insufficiency (premature ovarian failure) [PDF]
, 2007 Vien H. Vanderhoof +5 more
openalex +1 more source
Metabolomic Analysis of Sea Cucumber Ovum Hydrolysates in Cyclophosphamide-Induced Premature Ovarian Failure. [PDF]
FoodsWang X +7 more
europepmc +1 more source