Results 201 to 210 of about 2,087,459 (277)

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats

open access: yesAging Cell, Volume 25, Issue 9, September 2026.
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Subhasri Biswas   +11 more
wiley   +1 more source

Management of congenital female genital tract anomalies related to primary amenorrhea and/or cyclic abdominal pain: A retrospective cohort study

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1810-1822, September 2026.
Overall, 21 patients with uterine, cervical, and vaginal aplasia were treated successfully with neovagina formation. In 6 out of 8 patients, with obstructed uterine cavity, anastomosis was successful; one underwent hysterectomy and one elective hemi‐hysterectomy.
Grigoris F. Grimbizis   +5 more
wiley   +1 more source

Out of synchrony with the imagined self: A scoping review of self‐concept in premature ovarian insufficiency and early menopause

open access: yesBritish Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objective Premature ovarian insufficiency (POI) and early menopause (EM) can have life‐altering physical and psychological impacts, with potential consequences for an individual's sense of self. However, understanding of these potential consequences is limited, with much of the literature generalizing such experiences from naturally occurring ...
Lisa M. Seberry   +3 more
wiley   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

open access: yesCancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura   +3 more
wiley   +1 more source

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