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Oxidoreductase delivery by cell therapies in cyclophosphamide-induced premature ovarian insufficiency: a mechanistic insight into ovarian rejuvenation. [PDF]

J Ovarian Res
Zhang YY, Chen J, Yang W, Chen Y, Zhang Y, Zhou Y, Jin J, Mei Y, Huang D, Tong X, Zhang YL, Zhang S.   +11 more
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Premature ovarian insufficiency

BMJ
Premature ovarian insufficiency (POI) is a cause of infertility and endocrine dysfunction in women, defined by loss of normal, predictable ovarian activity before the age of 40 years. POI is clinically characterized by amenorrhoea (primary or secondary) with raised circulating levels of follicle-stimulating hormone.
Zachary, Nash, Melanie, Davies
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Premature ovarian insufficiency

Current Opinion in Endocrine and Metabolic Research, 2023
Natural menopause typically occurs between the ages of 46 to 55 years. Premature ovarian insufficiency or premature menopause refers to compromised ovarian follicular activity, occurring spontaneously or because of medical interventions, prior to the age of 40 years.
Svetlana Vujovic, Miomira Ivovic, Milina Tancic Gajic, Ljiljana Marina, Svetlana Dragojevic-Dikic   +4 more
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Premature ovarian insufficiency and infertility

Australian Journal of General Practice, 2023
Premature ovarian insufficiency (POI) is the loss of ovarian function before the age of 40 years and can be spontaneous or iatrogenic. It is an important cause of infertility, and the diagnosis should be considered in any woman presenting with oligo/amenorrhoea, even in the absence of menopausal symptoms suchas hot flushes.The aim of this article is to
Waduge, Dhanushi Fernando, Amanda, Vincent, Karen, Magraith   +2 more
openaire   +2 more sources

Sexuality in premature ovarian insufficiency

Climacteric, 2019
Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function.
Rossella E Nappi, Chiara Cassani
exaly   +4 more sources

Current Concepts in Premature Ovarian Insufficiency

Women's Health, 2015
Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood.
Kate Maclaran, Nick Panay
exaly   +3 more sources

Premature ovarian insufficiency

Endocrine Abstracts, 2014
Premature ovarian failure is defined as amenorrhea with hypo-oestrogenism and elevated gonadotrophins occurring before the age of 40 years. In theory, ovarian failure may occur because of a decreased pool of primordial follicles, because ovarian apoptosis is increased or accelerated or because the follicle maturation is interrupted before the ...
openaire   +2 more sources

Molecular Genetics of Premature Ovarian Insufficiency

Trends in Endocrinology and Metabolism, 2018
Premature ovarian insufficiency (POI) is highly heterogeneous in genetic etiology. Yet identifying causative genes has been challenging with candidate gene approaches. Recent approaches using next generation sequencing (NGS), especially whole exome sequencing (WES), in large POI pedigrees have identified new causatives and proposed relevant candidates,
Xue Jiao, Hanni Ke, Yingying Qin
exaly   +3 more sources

Diagnosis and management of premature ovarian insufficiency

Best Practice & Research Clinical Endocrinology & Metabolism, 2021
Premature ovarian insufficiency (POI) is a complex clinical syndrome with life-changing physiological and psychological consequence in young women of reproductive age. However, the understanding of the etiology, diagnosis and optimal intervention strategies for this condition remains poorly understood.
Rumana, Rahman, Nick, Panay
openaire   +2 more sources

Premature Ovarian Insufficiency: An Adolescent Series

Journal of Pediatric and Adolescent Gynecology, 2017
To study the presentation and causes of premature ovarian insufficiency (POI) in adolescents.Retrospective notes review.Tertiary referral outpatient clinic for pediatric and adolescent gynecology.Adolescents with POI.Standard POI evaluation.Age and clinical symptoms at presentation, causative factors for POI, if identified.We identified 22 girls with ...
Lina Michala
exaly   +4 more sources