Results 221 to 230 of about 516,689 (292)

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Subhasri Biswas, Hoang V. M. Nguyen, Aubrey Converse, Satoshi Matsuzaki, Michael T. Kinter, Kenneth M. Humphries, Willard M. Freeman, Sarah R. Ocañas, Arlan Richardson, Francesca E. Duncan, Tommy L. Lewis Jr, Michael B. Stout   +11 more
wiley   +1 more source

Establishment of an Autoimmune Premature Ovarian Insufficiency Mouse Model with Proteomic Analyses: An Exploratory Study. [PDF]

Int J Mol Sci
Tian Y, Zhou J, Pei X, Liu F, Diao F.
europepmc   +1 more source

Management of congenital female genital tract anomalies related to primary amenorrhea and/or cyclic abdominal pain: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1810-1822, September 2026.
Overall, 21 patients with uterine, cervical, and vaginal aplasia were treated successfully with neovagina formation. In 6 out of 8 patients, with obstructed uterine cavity, anastomosis was successful; one underwent hysterectomy and one elective hemi‐hysterectomy.
Grigoris F. Grimbizis, Sofia Tsiapakidou, Eirini Iordanidou, Georgios Kioussis, Anastasia Vatopoulou, Theodoros Theodoridis   +5 more
wiley   +1 more source

Premature ovarian insufficiency in patients with systemic lupus erythematosus on cyclophosphamide: a systematic review and meta-analysis. [PDF]

Front Endocrinol (Lausanne)
García-Sáenz MR, Ramírez-Rentería C, Espinosa-Cárdenas E, Sosa-Eroza E, Doval-Caballero JLE, Gete Palacios PC, Pazos-Pérez F, Ocampo-Torres MC, Catana-Hernández R, Vázquez-Zaragoza MÁ, Camargo-Coronel A, Gómez-Bernal JR, Ferreira-Hermosillo A.   +12 more
europepmc   +1 more source

Transmasculine pregnancy—Occurrence, associations, and outcomes: A quantitative systematic review

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1646-1661, September 2026.
This quantitative systematic review of 44 studies shows that a significant minority of transmasculine people become pregnant, including after transition. Miscarriage and postnatal depression rates appeared high, but there was minimal information on most other important outcomes, demonstrating that more research is needed.
Catherine Meads, Chelsea Daniels, Shawn Walker, Susan Bewley   +3 more
wiley   +1 more source

<i>All-in-one</i> exome sequencing approach for genetic testing of unexplained premature ovarian insufficiency. [PDF]

Hum Reprod Open
Valkna A, Kikas T, Jakovlev Ü, Mõttus O, Dutta A, Erlang K, Punab M, Rull K, Laan M.   +8 more
europepmc   +1 more source

Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells. [PDF]

Eur J Histochem
Su H, Ma R, Su D, Tan C, Zhu Y, Yang X.
europepmc   +1 more source

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Glycosylation in premature ovarian insufficiency: from genetic etiology to precision diagnostics. [PDF]

J Ovarian Res
Feng C, Qi N, Feng R, Liu Y, Yuan X.
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, Volume 105, Issue 3, Page 271-284, September 2026.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source