Results 141 to 150 of about 554,391 (236)

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1759-1771, September 2026.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Dysregulation of Peripheral Blood B Cells and Natural Killer Cells Is Associated With Myocarditis in Idiopathic Inflammatory Myopathies

ACR Open Rheumatology, Volume 8, Issue 9, September 2026.
Objective Idiopathic inflammatory myopathies (IIMs), or myositis, are a group of systemic autoimmune diseases leading to proximal muscle weakness. Myocarditis is a major cause of adverse outcomes. Yet, we know very little about the underlying immunologic processes that are driving myocarditis in the context of IIMs. Methods We performed single‐cell RNA
Carolina Duque, Sylvie T. Rousseau, Zuzana Bologna, Monica R. Mugnier, Luigi Adamo, Julie J. Paik   +5 more
wiley   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, Volume 36, Issue 75, 17 September 2026.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Gerrymandering in the heart: How tissue heterogeneities promote premature ventricular contractions. [PDF]

Biophys J
Sato D, Bers DM.
europepmc   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, Volume 13, Issue 53, 24 September 2026.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

AI &Innovation, Volume 1, Issue 2, September 2026.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury, Kandarpa Kumar Sarma, Lachit Dutta   +2 more
wiley   +1 more source

Angiography‐Negative Subarachnoid Hemorrhage Detected After Emergent Percutaneous Coronary Intervention for Non‐ST‐Segment Elevation Myocardial Infarction: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Neurological deterioration, headache, vomiting, bradycardia, or hypertension after emergent percutaneous coronary intervention should prompt immediate brain imaging. When subarachnoid hemorrhage is detected shortly after coronary stenting, the hemorrhage onset may remain uncertain, and antiplatelet decisions require individualized ...
Chul Hee Lee
wiley   +1 more source

Combined Application of a Helix‐Fixation Leadless Pacemaker and a Subcutaneous Implantable Cardioverter‐Defibrillator in a Dialysis Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Combined use of S‐ICD and LP provides an effective alternative for patients requiring defibrillation and pacing while avoiding transvenous leads. This strategy is particularly valuable for patients with a high risk of infection, though careful consideration must be given to minimizing potential device–device interactions.
ZhaoWei Zhou, Wenbo Zhang, Jie Pang, Ying Zhou   +3 more
wiley   +1 more source

Cardiac magnetic resonance imaging in patients referred for premature ventricular contractions: identifying patients most likely to benefit. [PDF]

Front Cardiovasc Med
Gomez A, Gun M, Otmani A, Leborgne L, Tribouilloy C, Vermes E.   +5 more
europepmc   +1 more source