Results 41 to 50 of about 49,147 (253)

Bioengineered Skin Grafts from Patient‐Derived Decellularized Extracellular Matrix and Autologous Cells for Personalized Regenerative

Advanced Science, EarlyView.
This study presents a patient‐specific skin model using autologous cells, decellularized dermal ECM, and keratin–alginate bioinks. The model supports cell compatibility, collagen deposition, and epidermal differentiation within a biomimetic ECM environment.
RaeHui Kang, Suyeon Shin, Yurim Choi, WonJun Jang, Soojin Park, Mi Kyung Lee, Hyun‐Jong Cho, Yu Shrike Zhang, Han‐Jun Kim, Bo Young Park, Junmin Lee   +10 more
wiley   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

A comparative study of efficacy of midazolam and triclofos as oral premedication in children undergoing minor surgical procedures [PDF]

Al Ameen Journal of Medical Sciences, 2023
Background: In Paediatric population, premedication is oftenly used to decrease preoperative anxiety, facilitate separation from parents and to get acceptance for face mask induction.
Meenal Agarwal, Surendrakumar Agarwal, Sunil Khyadi   +2 more
doaj  

Premedication for Iodinated Contrast Media Induced Immediate Hypersensitivity Reactions

Current Treatment Options in Allergy, 2019
Premedication using antihistamines and/or corticosteroids has been widely used to prevent reoccurrence of immediate hypersensitivity reactions (iHR) after iodinated contrast media (ICM).
R. Schrijvers, P. Demoly, A. Chiriac
semanticscholar   +1 more source

Biologically‐oriented alveolar ridge preservation to correct bone dehiscence at immediate implant placement

Clinical Advances in Periodontics, EarlyView.
Abstract Background The purpose of the present case study is to describe the application of a modification of the Biologically‐oriented Alveolar Ridge Preservation (BARP) principles in cases of peri‐implant bone dehiscence (PIBD) due to a compromised alveolus at immediate implant placement (IIP).
Leonardo Trombelli, Tommaso Grenzi
wiley   +1 more source

Comparative Evaluation of Intravenous Dexmedetomidine and Clonidine on the Extent and Duration of Bupivacaine Spinal Anaesthesia: A Randomised Control Trial [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Several methods have been tried in recent years to alleviate post-operative pain, with partial or greater success. Alpha 2 adrenergic agonists have analgesic property when used as an adjuvant to regional anaesthesia.
Akoijam Nikhil Singh, Amol Singam
doaj   +1 more source

Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study

Drug Design, Development and Therapy, 2018
Background Premedication is the most common way to minimize distress in children entering the operating room and to facilitate the smooth induction of anesthesia and is accomplished using various sedative drugs before the children are being transferred ...
S. Keles, Ozlem Kocaturk
semanticscholar   +1 more source

Safety and Efficacy Findings From a Phase Ib/II Study of ASP‐1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background ASP‐1929 photoimmunotherapy—cetuximab conjugated to IRDye 700DX and red light (690 nm) for localized drug activation—results in rapid, selective cell killing. Methods This phase Ib/II open‐label study evaluated ASP‐1929 photoimmunotherapy plus pembrolizumab in patients with recurrent/metastatic HNSCC (≥ 1 accessible lesion, PD‐L1 ...
David M. Cognetti, Joseph M. Curry, Jennifer Johnson, Michael Kwon, Shirley Y. Su, Francisco Civantos, Coral Olazagasti, Joseph Valentino, Susanne M. Arnold, R. Bryan Bell, Michael K. Gibson, Kyle Mannion, Kathryn M. Van Abel, Katharine A. Price, Haiying Dong, Amy H. Thorne, Toshiaki Suzuki, Ann M. Gillenwater   +17 more
wiley   +1 more source

Comparison of dexmedetomidine and three different doses of midazolam in preoperative sedation

Journal of Anaesthesiology Clinical Pharmacology, 2011
Background: This study was conducted to compare the efficacy and effects of dexmedetomidine and midazolam in preoperative sedation. Materials and Methods: A total of 125 patients in American Society of Anaesthesiologists (ASA) I-II were divided into ...
Gulay Eren, Zafer Cukurova, Guray Demir, Oya Hergunsel, Betul Kozanhan, Nalan S Emir   +5 more
doaj   +1 more source

Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization

Head &Neck, EarlyView.
ABSTRACT Background Alpha‐gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal).
Alexander G. Emerson, Lindsay Mundy, Barbara A. Murphy, Cosby A. Stone   +3 more
wiley   +1 more source