Results 41 to 50 of about 2,567,574 (274)

Maternal Substance Use: Consequences, Identification, and Interventions

Alcohol Research, 2020
Alcohol, tobacco, and cannabis are the substances most frequently used during pregnancy, and opioid-exposed pregnancies have increased fourfold.
Grace Chang
doaj   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Alcohol consumption among pregnant women in James Town Community, Accra, Ghana

Reproductive Health, 2017
Background Alcohol consumption among pregnant women is a public health concern, considering its adverse outcomes for both mother and the developing foetus.
Joanita Da Pilma Lekettey, Phyllis Dako-Gyeke, Samuel Agyei Agyemang, Moses Aikins   +3 more
doaj   +1 more source

Patterns of Prenatal Alcohol Exposure and Alcohol‐Related Dysmorphic Features [PDF]

Alcoholism: Clinical and Experimental Research, 2020
BackgroundIn animal models, it is possible to induce different alcohol‐related dysmorphic abnormalities based on the timing of prenatal alcohol exposure (PAE). Our objective was to assess whether patterns of PAE differentially predict alcohol‐related dysmorphic features in 415 infants.MethodsWe analyzed a prospective pregnancy cohort in western Ukraine
Bandoli, Gretchen, Jones, Ken, Wertelecki, Wladimir, Yevtushok, Lyubov, Zymak‐Zakutnya, Natalya, Granovska, Iryna, Plotka, Larysa, Chambers, Christina, CIFASD, The   +8 more
openaire   +4 more sources

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source

Prenatal exposure to alcohol does not affect radial maze learning and hippocampal mossy fiber sizes in three inbred strains of mouse

Behavioral and Brain Functions, 2005
Background The aim of this study was to investigate the effects of prenatal alcohol exposure on radial-maze learning and hippocampal neuroanatomy, particularly the sizes of the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields, in three ...
Bertholet Jean-Yves, Jamot Laure, Sluyter Frans, Crusio Wim E   +3 more
doaj   +1 more source

Auditory Outcomes in Adolescents with Prenatal Alcohol Exposure

Developmental Neuroscience, 2022
The aim of the study was to investigate three aspects of auditory function (auditory acuity, cochlear dysfunction, and auditory processing) in adolescents with fetal alcohol exposure without phenotypic changes. Fifty-one adolescents with and without intrauterine exposure to alcohol were selected from a cohort study.
Humberto de Oliveira Simões, Eduardo Tanaka Massuda, Erikson Felipe Furtado, Sthella Zanchetta   +3 more
openaire   +2 more sources

Maternal Factors Modifying the Link Between Genetic Risk for Autism and Developmental Milestones

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Although common genetic liability—quantified through polygenic risk scores (PRS)—accounts for substantial variance in autism spectrum disorder (ASD) liability, how prenatal environmental exposures interact with genetic predisposition to shape developmental outcomes remains poorly understood. Using the data from Autism Genetic Resource Exchange
Liliana D'Alesio, Vishani Nimish Patel, McKenna Walsh, Erick Messias, Ping‐I Lin   +4 more
wiley   +1 more source

Developing appropriate Fetal Alchohol Spectrum Disorder (FASD) prevention initiatives within a rural community in South Africa [PDF]

, 2012
Includes bibliographical references.This study focused on women who consumed alcohol during pregnancy. The study population was situated in the West Coast/Winelands, a rural area in the Western Cape Province of South Africa.
Cloete, Lizahn
core   +1 more source

Prenatal Alcohol Exposure and Cellular Differentiation

Alcohol Research, 2013
Exposure to alcohol significantly alters the developmental trajectory of progenitor cells and fundamentally compromises tissue formation (i.e., histogenesis).
Kylee J. Veazey, Daria Muller, Michael C. Golding   +2 more
doaj   +1 more source