Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. [PDF]
Biochem Cell Biol, 2018 The potential impact of prenatal alcohol exposure (PAE) varies considerably among exposed individuals, with some displaying serious alcohol-related effects and many others showing few or no overt signs of fetal alcohol spectrum disorder (FASD). In animal models, variables such as nutrition, genetic background, health, other drugs, and stress, as well ...
Petrelli B, Weinberg J, Hicks GG.
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Birth Defects Associated with Prenatal Alcohol Exposure—A Review [PDF]
Children, 2023 Since the recognition of fetal alcohol syndrome, alcohol has been accepted as a human teratogen. However, little is known about the relation between prenatal alcohol exposure and the spectrum of associated major birth defects.
Katarzyna Anna Dyląg +3 more
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Effect of chronic exposure of Losartan in mouse prenatal alcohol exposure (PAE) model
European Psychiatry, 2017 Background and aimsFoetal alcohol syndrome (FAS) is a condition that currently affects 1% of babies born in Europe and North America. It is characterised by memory impairment, developmental delay and distinctive facial features. This research uses a mouse prenatal alcohol exposure (PAE) model to explore the effects of PAE on learning, memory and to ...
A. Takyi
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Early prenatal alcohol exposure alters imprinted gene expression in placenta and embryo in a mouse model. [PDF]
PLoS ONE, 2018 Prenatal alcohol exposure (PAE) can harm the embryonic development and cause life-long consequences in offspring's health. To clarify the molecular mechanisms of PAE we have used a mouse model of early alcohol exposure, which is based on maternal ad ...
Heidi Marjonen +3 more
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Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders. [PDF]
Dev NeurobiolABSTRACT Individuals with fetal alcohol spectrum disorders exhibit impaired auditory processing and atypical auditory behaviors across the disorder's spectrum. Although low to moderate prenatal alcohol exposure (PAE) is a prevalent type of exposure, the developmental trajectory of auditory processing deficits resulting from this level of exposure ...
Douchey M +3 more
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Two-Stage Estimation for Causal Inference Involving Semi-Continuous Exposures. [PDF]
Stat MedABSTRACT Methods for causal inference are well developed for binary and continuous exposures, but in many settings, the exposure has a substantial mass at zero—such exposures are called semi‐continuous. We propose a general causal framework for such semi‐continuous exposures, together with a two‐stage estimation strategy.
Wang X +7 more
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Nailfold Capillary Morphology as a Potential Biomarker of Cardiovascular or Metabolic Risk in Children Aged 3-17 Years Prenatally Exposed to Alcohol. [PDF]
Alcohol Clin Exp Res (Hoboken)Children with prenatal alcohol exposure (PAE) exhibit early alterations in their microvasculature. Using nailfold capillaroscopy, a noninvasive imaging technique, we compared nailfold capillary morphology in 27 children with PAE and 10 unexposed peers (3–17 years).
Anunziata F +8 more
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Associations between prenatal alcohol exposure and parent-reported sleep disturbances in 10,336 adolescents: an Adolescent Brain Cognitive Development study. [PDF]
J Child Psychol PsychiatryBackground This study investigated the associations between prenatal alcohol exposure (PAE), including low and moderate levels of exposure, and parent‐reported sleep disturbances during adolescence. This is an area that remains understudied despite evidence linking PAE, particularly heavy PAE, to poor sleep in younger children and the growing ...
Devine EK +9 more
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Prenatal Alcohol Exposure Produces Selective Changes in Neuroimmune Gene Expression Across Brain Regions of Adult Mice. [PDF]
Alcohol Clin Exp Res (Hoboken)PAE creates a unique inflammatory signature in the mature adult brain with region‐specific changes in genes implicated in glial‐immune function. We report at least 60 differentially expressed genes in different brain regions due to PAE, many of which are associated with neuroimmune function.
Jones AN +6 more
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Construct and factorial validity of Neurobehavioral Disorder associated with Prenatal Alcohol Exposure (ND-PAE) [PDF]
BMC Psychology, 2020 AbstractBackgroundND-PAE, as a condition needing further study, requires validation. Few studies have assessed the validity of ND-PAE with none using a prospective sample.MethodsFifty-eight children underwent multidisciplinary FASD assessments and were evaluated for ND-PAE using a prospective, clinical approach.
James Ladell Sanders +2 more
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