Results 61 to 70 of about 2,552,713 (172)

Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke

iScience, 2023
Summary: Prenatal alcohol exposure (PAE) impairs recovery from cerebrovascular ischemic stroke in adult rodents. Since the gut becomes dysbiotic following stroke, we assessed links between PAE and enteric portal inflammation.
Marisa R. Pinson, Shameena Bake, David A. Hurst, Nadia T. Samiya, Farida Sohrabji, Rajesh C. Miranda   +5 more
doaj   +1 more source

Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. [PDF]

PLoS ONE, 2018
Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming.
Robyn M Amos-Kroohs, David W Nelson, Timothy A Hacker, Chi-Liang Eric Yen, Susan M Smith   +4 more
doaj   +1 more source

Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex

iScience, 2021
Summary: Prenatal alcohol exposure (PAE) results in cerebral cortical dysgenesis. Single-cell RNA sequencing was performed on murine fetal cerebral cortical cells from six timed pregnancies, to decipher persistent cell- and sex-specific effects of an ...
Nihal A. Salem, Amanda H. Mahnke, Kranti Konganti, Andrew E. Hillhouse, Rajesh C. Miranda   +4 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Fetal Alcohol Spectrum Disorder Awareness, Knowledge, and Practice Among Australian Occupational Therapists: A Cross‐Sectional Survey

Australian Occupational Therapy Journal, Volume 73, Issue 4, August 2026.
Abstract Introduction Fetal Alcohol Spectrum Disorder (FASD) describes a spectrum of birth defects and developmental disabilities resulting from prenatal alcohol exposure. With a prevalence rate of 3.64%, developing an FASD‐informed occupational therapy workforce is essential across all practice contexts. Since the Australian diagnostic guidelines were
Laine Chilman, Daniel Meloncelli, Alison Houghton, Asmita Mudholkar, Catherine Hilly   +4 more
wiley   +1 more source

Differential effects of prenatal alcohol exposure on brain growth reveals early upregulation of cell cycle and apoptosis and delayed downregulation of metabolism in affected offspring.

PLoS ONE
Fetal Alcohol Spectrum Disorder (FASD) encompasses the deleterious consequences of Prenatal Alcohol Exposure (PAE), including developmental delay, microcephaly, dysmorphologies, and cognitive and behavioral issues. The dose and timing of alcohol exposure,
Danielle Sambo, Ethan Kinstler, Yuhong Lin, David Goldman   +3 more
doaj   +1 more source

Increased Prevalence of Rare Copy Number Variants in Australian Children With Fetal Alcohol Spectrum Disorder: Experience in a State‐Wide Diagnostic Service

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Of 175 Australian children with fetal alcohol spectrum disorder (FASD), 90% had genetic testing, and of those, 24% had a rare copy number variant (CNV). Genetic testing supports the FASD diagnostic process and may reveal additional diagnoses or sources of genetic vulnerability to FASD.
Suzy Byrnes, Felicity Collins, Elizabeth Elliott   +2 more
wiley   +1 more source

Prenatal alcohol history – setting a threshold for diagnosis requires a level of detail and accuracy that does not exist

BMC Pediatrics, 2019
Background The revised 2015 Canadian Guidelines requires a more specific prenatal alcohol exposure (PAE) threshold for a Fetal Alcohol Spectrum Disorder (FASD) diagnosis.
Susan Petryk, Muhammad A. Siddiqui, Juliet Ekeh, Mamata Pandey   +3 more
doaj   +1 more source

Thyroid Function in Pregnant Women With Moderate to Severe Alcohol Consumption Is Related to Infant Developmental Outcomes

Frontiers in Endocrinology, 2018
IntroductionFetal alcohol spectrum disorders (FASD) have an estimated global prevalence of 2–5% of births, but prevalence is reported to be as high as 15.5% for FASD in certain high-risk communities in South Africa.
Kirsten A. Donald, Catherine J. Wedderburn, Catherine J. Wedderburn, Whitney Barnett, Whitney Barnett, Nadia Hoffman, Heather J. Zar, Heather J. Zar, Eva E. Redei, Eva E. Redei, Dan J. Stein, Dan J. Stein   +11 more
doaj   +1 more source

Prenatal Alcohol Exposure and Infant Cognitive Development [PDF]

, 2015
The association between heavy prenatal alcohol exposure (PAE) and impaired cognitive development in children has been well documented, yet uncertainty remains regarding the effects of low-level PAE. This thesis, after reviewing evidence in Chapter 1, and
McCormack, Clare
core   +1 more source