Results 81 to 90 of about 66,942 (274)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). [PDF]

, 2019
ObjectiveTo evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.MethodsWe performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320).
Aucott, Susan W, Bulbul, Ali, Carey, William A, Clyman, Ronald I, Derrick, Matthew, Dong, Lawrence, Erdeve, Omer, Farooqi, Aijaz, Hassinger, Denise C, Hayashi, Madoka, Heuchan, Anne Marie, Håkansson, Stellan, Kaempf, Joseph, Katheria, Anup, Kimball, Amy, Leone, Tina, Liebowitz, Melissa, Lindqvist, Johanna, Nelson, Kelly, Perez, Jorge, Sankar, Meera, Sauberan, Jason, Serize, Arturo, Singh, Jaideep, Wickremasinghe, Andrea, Wolf, Ilene Sue   +25 more
core   +1 more source

Maternal Gestational Low‐Grade Inflammation and the Risk of Anorexia Nervosa in Daughters

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Prenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gestational high‐sensitivity C‐reactive protein (hs‐CRP), an established inflammatory biomarker, and subsequent
Emma Saure, Pyry N. Sipilä, Cynthia M. Bulik, Elina Santti, Heljä‐Marja Surcel, Antti Latvala, Anu Raevuori   +6 more
wiley   +1 more source

Endocrine disruptors and abnormalities of pubertal development [PDF]

, 2008
Onset and development of puberty is regulated by the neuroendocrine system. Population-based studies worldwide have observed secular trends towards earlier puberty development. These changes are apparently caused by environmental factors such as improved
Adair, Adair, Berg-Kelly, Blanck, Colon, DeCastro, Den Hond, Den Hond, Dunger, Gamba, Gladen, Gore, Grumbach, Guo, Hertz-Picciotto, Ibanez, Kaya, Klein, Krstevska-Konstantinova, Kubo, Kuhl, Lebrethon, Lee, Legler, Levine, Levy, Lewis, Marshall, Marshall, McKee, McLachlan, Mol, Naftolin, Ohtake, Parent, Patton, Petroff, Proos, Ramirez, Rasier, Rockett, Roselli, Rubin, Safe, Sagiv, Saiyed, Selevan, Singh, Skynner, Staessen, Styne, Teilmann, Tena-Sempere, Tena-Sempere, Terasawa, Traggiai, Vasiliu, Vinggaard, Wade, Warner, Wu, Wu, Zeinoaldini   +62 more
core   +2 more sources

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Potential Mechanism Connecting Preeclampsia to Autism Spectrum Disorder in Offspring: The Role of Microglial Abnormalities

Frontiers in Bioscience-Landmark
Preeclampsia (PE) is a serious complication of pregnancy characterized by chronic inflammation and immune dysregulation, which significantly increases the risk of neurodevelopmental disorders in offspring, including the autism spectrum disorder (ASD ...
Ying Zhu, Si-Yi Wei, Xiao-Tong Fu, Xi Cheng, Xian-Hua Lin   +4 more
doaj   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Nicotine ameliorates schizophrenia-like cognitive deficits induced by maternal LPS exposure: a study in rats

Disease Models & Mechanisms, 2016
Maternal exposure to infectious agents is a predisposing factor for schizophrenia with associated cognitive deficits in offspring. A high incidence of smoking in these individuals in adulthood might be, at least in part, due to the cognitive-enhancing ...
Uta Waterhouse, Vic E. Roper, Katharine A. Brennan, Bart A. Ellenbroek   +3 more
doaj   +1 more source

Early probiotic supplementation for the prevention of atopic disease in newborns-probiotics and the hygiene hypothesis-. [PDF]

, 2011
Environmental factors during early infancy could theoretically affect immune system development and subsequent risk of allergic disease. One potentially helpful exposure is early infant supplementation with specific probiotic strains.
Cabana, Michael D
core   +3 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source