Results 121 to 130 of about 209,608 (344)

Prenatal Stress: A Predictor of Childhood Behavior Disorders [PDF]

Background: Behavior disorders in children are disruptive to the lives of those who are close to the child and can affect life in the home, school or social setting.
Trasen, Robyn S
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Examining the reversibility of long-term behavioral disruptions in progeny of maternal SSRI exposure [PDF]

, 2018
Serotonergic dysregulation is implicated in numerous psychiatric disorders. Serotonin plays widespread trophic roles during neurodevelopment; thus perturbations to this system during development may increase risk for neurodevelopmental disorders ...
Akula, Shyam, Chandler, Krystal, Corbett, Adrian M, Dougherty, Joseph D, Maloney, Susan E, McCullough, Katherine B, McGowin, Audrey E, Rieger, Michael A   +7 more
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Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
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Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Putting Families First: How the Opioid Epidemic is Affecting Children and Families, and the Child Welfare Policy Options to Address It [PDF]

, 2019
: Opioids and Child Welfare Across the country, placements in foster care are rising. In 2016, the U.S. Department of Health and Human Services reported that 273,539 children in the U.S. entered foster care.
American Academy of Pediatrics Council on Foster Care, Adoption, and Kinship Care, Greiner, Mary V, Laris, Zach, Waite, Douglas   +3 more
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Trabecular bone ontogeny of the human talus

The Anatomical Record, EarlyView.
Abstract Studies of trabecular ontogeny may provide insight into the factors that drive healthy bone development. There is a growing understanding of how the juvenile skeleton responds to these influences; however, gaps in our knowledge remain. This study aims to identify ontogenetic trabecular patterns and regional changes during development within ...
Rebecca A. G. Reid, Catriona Davies, Craig Cunningham   +2 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

The Effect of Prenatal Stress on Birth Weight: Evidence from the al-Aqsa Intifada [PDF]

No previous study has attempted to estimate the effect of intrauterine exposure to armed conflict, a potential source of stress, on pregnancy outcomes. Drawing on data from the 2004 Palestinian Demographic and Health Survey, we examine the relationship ...
Daniel I. Rees, Hani Mansour
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