Animal Research and One Health, EarlyView.Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao +12 more
wiley +1 more source
Interval Timing Is Altered in Male Nrxn1+/− Mice: A Model of Autism Spectrum Disorder
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication, and increased repetitive and stereotypical behavior. Neuroimaging shows functional abnormalities in brain areas involved in temporal processing in autistic individuals, and they also show deficits in interval timing.
Kyle M. Roddick +3 more
wiley +1 more source
Effects of a Mindfulness-Based Intervention on Distress, Weight Gain, and Glucose Control for Pregnant Low-Income Women: A Quasi-Experimental Trial Using the ORBIT Model. [PDF]
, 2019 BackgroundStress can lead to excessive weight gain. Mindfulness-based stress reduction that incorporates mindful eating shows promise for reducing stress, overeating, and improving glucose control. No interventions have tested mindfulness training with a
Adler, N +13 more
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Correction: Marrocco et al., Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus [PDF]
, 2013 Jordan Marrocco +10 more
openalex +1 more source
The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source
Prenatal Exposure to Stress and Lung Function in 8-10 year old Children
, 2020 Marcela Tamayo‐Ortiz +11 more
openalex +1 more source
Prenatal Stress Alters Transcription of NMDA Receptors in the Frontal Cortex and Hippocampus [PDF]
, 2023 Tristram Buck, Monsheel Sodhi
openalex +1 more source
Autism Research, EarlyView.ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis.
Laura Sandoni +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić +7 more
wiley +1 more source
Serotonin Transporter Knockout Mice and Maternal Stress: A Potential Animal Model of Autism [PDF]
, 2008 This study examined whether an interaction between the serotonin transporter genotype and maternal stress results in a mouse with characteristics of autism.
Lindsay, Karen
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