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Prenylation: A Critical Step for Biomanufacturing of Prenylated Aromatic Natural Products
Journal of Agricultural and Food Chemistry, 2023Prenylated aromatic natural products (PANPs) have received much attention due to their biomedical benefits for human health. The prenylation of aromatic natural products (ANPs), which is mainly catalyzed by aromatic prenyltransferases (aPTs), contributes significantly to their structural and functional diversity by providing higher lipophilicity and ...
Ting An, Xudong Feng, Chun Li
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BioEssays, 1992
AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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Inhibitors of prenyl transferases
Current Opinion in Oncology, 1997Because farnesylation of Ras is required for its cancer-causing activity, several classes of farnesyl transferase inhibitors have recently been developed as potential anticancer drugs. During the last 12 months, important advances have been made in this field.
S, Sebti, A D, Hamilton
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Prenylated proteins from kidney
Biochemical and Biophysical Research Communications, 1986When [5-3H]mevalonate is injected into mice, it is incorporated into macromolecules in the kidney. The incorporated material is stable to treatment with RNase or DNase but not protease, indicating that the radioactivity is associated with protein. Electrophoresis in sodium dodecyl sulfate-containing polyacrylamide gels indicates a molecular weight of ...
E, Bruenger, H C, Rilling
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Prenylated Flavonoids: Pharmacology and Biotechnology
Current Medicinal Chemistry, 2005Within the flavonoid class of natural products the prenylated sub-class is quite rich in structural variety and pharmacological activity. In the last twenty years a huge number of new structures has been reported, mostly from Leguminosae and Moraceae, with few coming from other genera.
BOTTA, Bruno +4 more
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Antigenic Prenylated Peptide Conjugates and Polyclonal Antibodies To Detect Protein Prenylation
Bioconjugate Chemistry, 2004Posttranslational modification of proteins with farnesyl and geranylgeranyl groups is a required modification for signaling proteins that includes the small GTPases in the Ras, Rho, and Rab families, heterotrimeric G proteins, and nuclear lamin proteins.
Xiao-hui, Liu +3 more
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Zinc-Mediated Highly α-Regioselective Prenylation of Imines with Prenyl Bromide
Organic Letters, 2012A highly α-regioselective prenylation of imines has been successfully developed. The efficiency of this approach is confirmed by a wide range of imines including N- and C-aryl aldimines, N-alkyl aldimines, C-alkyl aldimines, and N- and C-aryl ketimines.
Li-Ming, Zhao +4 more
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ChemInform Abstract: A STUDY OF DE‐O‐PRENYLATION OF O‐PRENYL‐ AND C‐PRENYL‐O‐PRENYLPOLYPHENOLS
Chemischer Informationsdienst, 1978AbstractDer Prenylether (Ia) wird in wäßrigem Morpholin zum Phenol (Ib) gespalten.
A. C. JAIN, D. K. TULI, A. KOHLI
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Chemischer Informationsdienst, 1974
AbstractReaktion der Titelverbindung (I) mit dem Carbinol (II) liefert ein Gemisch der Prenylderivate (IIIa)‐(IIIc); bei der Umsetzung von (I) mit Prenylbromid (IV) werden nur (IIIb) und (IIIc) erhalten.
S. M. ANAND, A. C. JAIN
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AbstractReaktion der Titelverbindung (I) mit dem Carbinol (II) liefert ein Gemisch der Prenylderivate (IIIa)‐(IIIc); bei der Umsetzung von (I) mit Prenylbromid (IV) werden nur (IIIb) und (IIIc) erhalten.
S. M. ANAND, A. C. JAIN
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Prenylated isoflavonoids from Millettia pervilleana
Phytochemistry, 2003From the root bark of Millettia pervilleana, which had shown significant cytotoxic activity, a 3-phenylcoumarin, named pervilleanine, two new pterocarpans, pervilline and pervillinine, and one known, emoroidocarpan, were isolated in addition to rotenone and 3alpha-hydroxyrotenone.
Giovanna Palazzino +4 more
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