Results 121 to 130 of about 3,663 (218)

Prenylation of a Nonaromatic Carbon of Indolylbutenone by a Fungal Indole Prenyltransferase

, 2016
FtmPT1 from Aspergillus fumigatus is a fungal indole prenyltransferase (PT) that normally catalyzes the regiospecific prenylation of brevianamide F (cyclo-l-Trp-l-Pro) at the C-2 position of the indole ring with dimethylallyl diphosphate (DMAPP ...
Takahiro Mori (730485), Hiroyuki Morita (505542), Toshiyuki Wakimoto (1452055), Hiroshi Noguchi (610885), Jing Chen (4762), Ikuro Abe (1433923)   +5 more
core   +1 more source

Discovery of 1,4-Didydroxy-2-naphthoate Prenyltransferase Inhibitors:  New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens

, 2016
Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as
Michio Kurosu (2042068), Kallolmay Biswas (1960024), Dean C. Crick (364125), Prabagaran Narayanasamy (2479210), Rakesh Dhiman (2479207)   +4 more
core   +1 more source

Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals

, 2018
By the genome-mining approach, a chimeric enzyme of prenyltransferase-diterpene synthase was discovered from Penicillium chrysogenum MT-12. Since its product exhibited broadened NMR signals, the structural determination by only the NMR analysis was ...
Makoto Fujita, Masahiro Ozeki (5666675), Masahiro Ozeki, Takaaki Mitsuhashi, Makoto Fujita (1510177), Takayoshi Awakawa (1528696), Takayoshi Awakawa, She-Po Shi, Takaaki Mitsuhashi (1433932), Takashi Kikuchi (1510180), Shotaro Hoshino (601862), Takashi Kikuchi, She-Po Shi (2394322), Ikuro Abe, Shotaro Hoshino, Ikuro Abe (1433923)   +15 more
core   +1 more source

Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice

, 2004
Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice.BackgroundMice that are homozygous for the kidney disease (kd) mutation are apparently healthy for the first 8 weeks of life, but spontaneously ...
Eric G. Neilson, Meade, Ray, George, Alfred L., Ray Meade, David L. Gasser, Jarett, Leonard, Gasser, David L., Madaio, Michael P., Neilson, Eric G., Michael P. Madaio, Peng, Min, Hancock, Wayne W., Alfred L. George, Wayne W. Hancock, Min Peng, Leonard Jarett   +15 more
core   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source

A Fungal Promiscuous UbiA Prenyltransferase Expands the Structural Diversity of Chrodrimanin-Type Meroterpenoids

Prenyltransferases play important roles in the diversification of natural products and the improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate promiscuity was identified as the pivotal builder of the noncanonical ...
Chuanteng Ma (10163706), Kaijin Zhang (8352042), Dehai Li (1433623), Tianjiao Zhu (1433617), Qian Che (725671), Junyu Liu (479315), Guojian Zhang (1604386), Xuewen Hou (3525002)   +7 more
core   +1 more source

Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids

, 2006
Posttranslational modification of proteins with farnesyl and geranylgeranyl isoprenoids is a widespread phenomenon in eukaryotic organisms. Isoprenylation is conferred by three protein prenyltransferases: farnesyl transferase (FTase), geranylgeranyl ...
Delon, Christine, Alexandrov, K., Dursina, Beatrice, Waldmann, Herbert, Veligodsky, Alexei, Alexandrov, Kirill, Kalinin, A., Szedlacsek, Stefan, E., Kulharia, M., Veligodsky, A., Thutewohl, M., Wu, Y., Ciobanu, D., Goody, Roger, S., Goody, R., Kulharia, Mahesh, Szedlacsek, S., Waldmann, H., Thutewohl, Michael, Wu, Yaowen, W., Evstifeev, Vladimir, Reents, R., Ciobanu, Doina, Kalinin, Alexandr, Evstifeev, V., Reents, Reinhard, Dursina, B., Delon, C.   +27 more
core   +1 more source

A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley

, 2014
International audienceFuranocoumarins constitute a sub-family of coumarin compounds with important defense properties against pathogens and insects, as well as allelopathic functions in plants. Furanocoumarins are divided into two sub-groups according to
Bourgaud, Frederic, Karamat, Fazeelat, Hehn, Alain, Olry, Alexandre, Sugiyama, Akifumi, Munakata, Ryosuke, Koeduka, Takao, Paris, Cedric, Yazaki, Kazufumi   +8 more
core   +1 more source

Geranylation of Chalcones by a Fungal Aromatic Prenyltransferase

Geranylated chalcones mainly exist in plants, and many of them have attracted attention because of their diverse pharmacological and biological activities.
Song Yang (162335), Kang Zhou (122652), Linlan Tao (14309701), Chun-Mao Yuan (1475944), Qianqian Ran (14768310), Xiang Zhou (164107), Shu-Ming Li (1523233)   +6 more
core   +1 more source

Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines

Nature Communications
Prenylation modifications of natural products play essential roles in chemical diversity and bioactivities, but imidazole modification prenyltransferases are not well investigated.
Wenxue Wang, Peng Wang, Chuanteng Ma, Kang Li, Zian Wang, Yuting Liu, Lu Wang, Guojian Zhang, Qian Che, Tianjiao Zhu, Yuzhong Zhang, Dehai Li   +11 more
doaj   +1 more source