Results 111 to 120 of about 3,663 (218)

gem-Diprenylation of Acylphloroglucinols by a Fungal Prenyltransferase of the Dimethylallyltryptophan Synthase Superfamily

, 2016
Aspergillus terreus aromatic prenyltransferase (AtaPT) catalyzes predominantly C-monoprenylation of acylphloroglucinols in the presence of different prenyl diphosphates.
Kang Zhou (122652), Jungui Dai (610572), Carsten Wunsch (3604916), Shu-Ming Li (1523233)   +3 more
core   +1 more source

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

Nature Communications, 2019
The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I ...
Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys   +7 more
doaj   +1 more source

Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development

, 2019
Prenyltransferase (PT) biocatalysts are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors.
Aoun, Ahmed R
core   +1 more source

Identification and Specificity Profiling of Protein Prenyltransferase Inhibitors Using New Fluorescent Phosphoisoprenoids

, 2016
Posttranslational modification of proteins with farnesyl and geranylgeranyl isoprenoids is a widespread phenomenon in eukaryotic organisms. Isoprenylation is conferred by three protein prenyltransferases:  farnesyl transferase (FTase), geranylgeranyl ...
Alexandr Kalinin (2648449), Doina Ciobanu (2648437), Beatrice Dursina (2648452), Reinhard Reents (2534818), Roger S. Goody (37534), Yaowen Wu (2057167), Stefan E. Szedlacsek (372925), Alexei Veligodsky (2648443), Christine Delon (497868), Mahesh Kulharia (2412658), Michael Thutewohl (2648446), Herbert Waldmann (497871), Kirill Alexandrov (234705), Vladimir Evstifeev (2648440)   +13 more
core   +2 more sources

Mechanism of dimethylallyltryptophan synthase: Evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction

, 2009
Dimethylallyltryptophan synthase is an aromatic prenyltransferase that catalyzes an electrophilic aromatic substitution reaction between dimethylallyl diphosphate (DMAPP) and l-tryptophan.
Luk, Louis Yu Pan, Tanner, Martin E.
core   +1 more source

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
doaj   +1 more source

Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom)

Molecules
Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies ...
Riccardo Iacovelli, Fons Poon, Kristina Haslinger   +2 more
doaj   +1 more source

Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.

, 2005
Activating K-ras mutations are found in approximately 90% of pancreatic carcinomas and may contribute to the poor prognosis of these tumors. Because radiotherapy is frequently used in pancreatic cancer treatment, we assessed the contribution of oncogenic
Brunner, TB, Wu, Junmin, Hahn, Stephen M., Hahn, SM, Wu, J, Brunner, Thomas, McKenna, William Gillies, Cengel, Keith A., Fraker, DL, Fraker, Douglas L., Cengel, KA, Mckenna, William, Mckenna, WG, Bernhard, EJ, Bernhard, Eric J.   +14 more
core   +1 more source

The synthesis and evaluation of natural/unnatural substrates of lepidopteran prenyltransferase

, 1997
Juvenile hormone (JH) is vital to normal insect growth and development. In the lepidopteran species of Manduca Sexta, JH consists of five different methyl epoxy-farnesoate homologs, which are produced via the terpenoid biosynthetic pathway ...
Ewing, Gregory James
core  

Lyngbyatoxin Biosynthesis:  Sequence of Biosynthetic Gene Cluster and Identification of a Novel Aromatic Prenyltransferase

, 2016
The lyngbyatoxins are potent skin irritants produced by Lyngbya majuscula and cause a condition known as “Swimmer's Itch” off Honolulu, HI. Reported is the molecular cloning of the lyngbyatoxin (ltx) biosynthetic gene cluster from L.
Daniel J. Edwards (2323762), William H. Gerwick (176359)   +1 more
core   +1 more source