Results 111 to 120 of about 3,960 (214)

Identification and Specificity Profiling of Protein Prenyltransferase Inhibitors Using New Fluorescent Phosphoisoprenoids

, 2016
Posttranslational modification of proteins with farnesyl and geranylgeranyl isoprenoids is a widespread phenomenon in eukaryotic organisms. Isoprenylation is conferred by three protein prenyltransferases:  farnesyl transferase (FTase), geranylgeranyl ...
Alexandr Kalinin (2648449), Doina Ciobanu (2648437), Beatrice Dursina (2648452), Reinhard Reents (2534818), Roger S. Goody (37534), Yaowen Wu (2057167), Stefan E. Szedlacsek (372925), Alexei Veligodsky (2648443), Christine Delon (497868), Mahesh Kulharia (2412658), Michael Thutewohl (2648446), Herbert Waldmann (497871), Kirill Alexandrov (234705), Vladimir Evstifeev (2648440)   +13 more
core   +2 more sources

Mechanism of dimethylallyltryptophan synthase: Evidence for a dimethylallyl cation intermediate in an aromatic prenyltransferase reaction

, 2009
Dimethylallyltryptophan synthase is an aromatic prenyltransferase that catalyzes an electrophilic aromatic substitution reaction between dimethylallyl diphosphate (DMAPP) and l-tryptophan.
Luk, Louis Yu Pan, Tanner, Martin E.
core   +1 more source

Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom)

Molecules
Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies ...
Riccardo Iacovelli, Fons Poon, Kristina Haslinger   +2 more
doaj   +1 more source

Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.

, 2005
Activating K-ras mutations are found in approximately 90% of pancreatic carcinomas and may contribute to the poor prognosis of these tumors. Because radiotherapy is frequently used in pancreatic cancer treatment, we assessed the contribution of oncogenic
Brunner, TB, Wu, Junmin, Hahn, Stephen M., Hahn, SM, Wu, J, Brunner, Thomas, McKenna, William Gillies, Cengel, Keith A., Fraker, DL, Fraker, Douglas L., Cengel, KA, Mckenna, William, Mckenna, WG, Bernhard, EJ, Bernhard, Eric J.   +14 more
core   +1 more source

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
doaj   +1 more source

Lyngbyatoxin Biosynthesis:  Sequence of Biosynthetic Gene Cluster and Identification of a Novel Aromatic Prenyltransferase

, 2016
The lyngbyatoxins are potent skin irritants produced by Lyngbya majuscula and cause a condition known as “Swimmer's Itch” off Honolulu, HI. Reported is the molecular cloning of the lyngbyatoxin (ltx) biosynthetic gene cluster from L.
Daniel J. Edwards (2323762), William H. Gerwick (176359)   +1 more
core   +1 more source

Prenylation of a Nonaromatic Carbon of Indolylbutenone by a Fungal Indole Prenyltransferase

, 2016
FtmPT1 from Aspergillus fumigatus is a fungal indole prenyltransferase (PT) that normally catalyzes the regiospecific prenylation of brevianamide F (cyclo-l-Trp-l-Pro) at the C-2 position of the indole ring with dimethylallyl diphosphate (DMAPP ...
Takahiro Mori (730485), Hiroyuki Morita (505542), Toshiyuki Wakimoto (1452055), Hiroshi Noguchi (610885), Jing Chen (4762), Ikuro Abe (1433923)   +5 more
core   +1 more source

Discovery of 1,4-Didydroxy-2-naphthoate Prenyltransferase Inhibitors:  New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens

, 2016
Since utilization of menaquinone in the electron transport system is a characteristic of Gram-positive organisms, the 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) inhibitors 1a and 2a act as selective antibacterial agents against organisms such as
Michio Kurosu (2042068), Kallolmay Biswas (1960024), Dean C. Crick (364125), Prabagaran Narayanasamy (2479210), Rakesh Dhiman (2479207)   +4 more
core   +1 more source

Crystalline Sponge Method Enabled the Investigation of a Prenyltransferase-terpene Synthase Chimeric Enzyme, Whose Product Exhibits Broadened NMR Signals

, 2018
By the genome-mining approach, a chimeric enzyme of prenyltransferase-diterpene synthase was discovered from Penicillium chrysogenum MT-12. Since its product exhibited broadened NMR signals, the structural determination by only the NMR analysis was ...
Makoto Fujita, Masahiro Ozeki (5666675), Masahiro Ozeki, Takaaki Mitsuhashi, Makoto Fujita (1510177), Takayoshi Awakawa (1528696), Takayoshi Awakawa, She-Po Shi, Takaaki Mitsuhashi (1433932), Takashi Kikuchi (1510180), Shotaro Hoshino (601862), Takashi Kikuchi, She-Po Shi (2394322), Ikuro Abe, Shotaro Hoshino, Ikuro Abe (1433923)   +15 more
core   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source