Results 91 to 100 of about 12,508 (203)

Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment.

, 2002
Early postnatal maternal deprivation leads to a variety of biochemical and behavioural alterations in the offspring, some of which do not develop until adulthood, like deficits in prepulse inhibition.
Cools, A.R., Ellenbroek, A.A.
core   +1 more source

Sex differences in prepulse inhibition deficits in chronic schizophrenia

, 2004
Recent years have seen a dramatic growth in the number of studies using prepulse inhibition (PPI) paradigms to index information processing deficits in schizophrenia.
Aasen, I, Kumari, V, Tonmoy Sharma, Ingrid Aasen, Sharma, T, Veena Kumari   +5 more
core   +1 more source

Role of the NMDA-receptor in Prepulse Inhibition in the Rat

International Journal of Tryptophan Research, 2010
Kynurenic acid (KYNA) is an endogenous metabolite of tryptophan. Studies have revealed increased brain KYNA levels in patients with schizophrenia. Prepulse inhibition (PPI) is a behavioral model for sensorimotor gating and found to be reduced in schizophrenia.
Klas, Linderholm, Susan, Powell, Elin, Olsson, Maria, Holtze, Ralph, Snodgrass, Sophie, Erhardt   +5 more
openaire   +2 more sources

Prepulse inhibition of the startle response in men with schizophrenia - Effects of age of onset of illness, symptoms, and medication

, 2000
Background: Prepulse inhibition of the startle reflex response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus.
Soni, W, Kumari, V, Mathew, V M, Sharma, T   +3 more
core   +1 more source

Inhibitory effects of prepulse stimuli on the electrophysiological responses to startle stimuli in the deep layers of the superior colliculus

Frontiers in Neuroscience
BackgroundPrepulse inhibition (PPI) is a phenomenon where a weak prepulse stimulus inhibits the startle reflex to a subsequent stronger stimulus, which can be induced by various sensory stimulus modalities such as visual, tactile, and auditory stimuli ...
Yu Ding, Yu Ding, Huan Jiang, Na Xu, Na Xu, Liang Li   +5 more
doaj   +1 more source

Minocycline and risperidone prevent microglia activation and rescue behavioral deficits induced by neonatal intrahippocampal injection of lipopolysaccharide in rats.

PLoS ONE, 2014
BackgroundVarious signs of activation of microglia have been reported in schizophrenia, and it is hypothesized that microglia activation is closely associated with the neuropathology of schizophrenia.MethodsNeonatal intrahippocampal injection of ...
Furong Zhu, Yingjun Zheng, Yu-qiang Ding, Yong Liu, Xianghui Zhang, Renrong Wu, Xiaofeng Guo, Jingping Zhao   +7 more
doaj   +1 more source

GAT1 KO mice show impaired prepulse inhibition and latent inhibition.

, 2013
A1, Startle amplitude to a 120 dB acoustic stimulus was normal in GAT1 KO mice. A2, GAT1 KO mice exhibited significantly reduced percent prepulse inhibition of the acoustic startle response across prepulse intensities (70, 75, 80 dB).
Jian Fei (95896), Tian-Le Xu (262261), Zhe Yu (44694), Hui Cao (182176), Zhong Chen (32985), Yi-Zhi Wang (438881), Gang Hu (132827), Neng Gong (270305), Qi Fang (199280), Xian Xiao (438880), You-Qing Cai (438882)   +10 more
core   +1 more source

Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density

Brain and Behavior
Purpose Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in
Sara G. Higarza, Marina De Antón‐Cosío, Candela Zorzo, Jorge L. Arias, Natalia Arias   +4 more
doaj   +1 more source

Startle response and prepulse inhibition in GluD1-KO mice.

, 2020
(A) Acoustic startle response test: Startle responses amplitudes were dependent on pulse intensity (WT, n = 7; GluD1-KO, n = 9) (two-way ANOVA: F7,112 = 24.2, p 1,112 = 0.08, p = 0.78), and no interaction between genotype and tone intensity (F7,112 = 0 ...
Chihiro Nakamoto (8474175), Keizo Takao (105704), Meiko Kawamura (8474178), Kenji Sakimura (47744), Rie Natsume (8474184), Masahiko Watanabe (47746), Tomonori Takeuchi (47736), Ena Nakatsukasa (8474181), Manabu Abe (362853)   +8 more
core   +1 more source

Prepulse inhibition of startle-induced reductions of accumbens dopamine [Abstract]

, 1995
Schizophrenia patients exhibit deficits in the prepulse inhibition of startle, an operational measure of the sensorimotor gating dysfunctions that may contribute to cognitive disorganization. In rats, activation of mesolimbic dopamine (DA) receptors (e.g.
Wilkinson, Lawrence Stephen, Robbins, T. W., Humby, Trevor, Geyer, M. A.   +3 more
core   +1 more source