Results 81 to 90 of about 12,508 (203)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Effect of Visuospatial Attention on the Sensorimotor Gating System

Frontiers in Behavioral Neuroscience, 2019
The integration of multiple sensory modalities allows us to adapt to the environment of the outside world. It is widely known that visual stimuli interfere with the processing of auditory information, which is involved in the ability to pay attention ...
Daisuke Ishii, Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno   +8 more
doaj   +1 more source

Precocial Weaning Influences Anxiety, Social and Maternal Care but Not Cognition in African Striped Mice, Rhabdomys dilectus chakae

Developmental Psychobiology, Volume 68, Issue 2, March 2026.
ABSTRACT Weaning is a stressful stage in the lives of young mammals. Early weaning, in particular, can lead to long‐lasting physiological and psychological changes. We investigated the effects of precocial weaning on anxiety, social behavior, cognition, and maternal behavior in adult African four‐striped mice (Rhabdomys dilectus chakae). Mice weaned at
Maria K Oosthuizen, Neville Pillay
wiley   +1 more source

Acoustic Startle with prepulse inhibition.

, 2013
Startle response was measured following exposure to a 120 dB tone. For prepulse (PP) inhibition, tone was preceded by a softer tone of either 70 or 76 dB.
Michael T. Williams (357796), Joseph F. Clark (103796), Matthew R. Skelton (357788), Charles V. Vorhees (357797), Tori L. Schaefer (357790), Devon L. Graham (357792), Ton J. deGrauw (357794)   +6 more
core   +1 more source

BDNF deficiency and young-adult methamphetamine induce sex-specific effects on prepulse inhibition regulation

Frontiers in Cellular Neuroscience, 2013
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of schizophrenia, yet its role in the development of specific symptoms is unclear. Methamphetamine (METH) users have an increased risk of psychosis and schizophrenia, and
Elizabeth E Manning, Maarten eVan Den Buuse   +1 more
doaj   +1 more source

Cocaine strongly reduces prepulse inhibition in apomorphine-susceptible rats, but not in apomorphine-unsusceptible rats: regulation by dopamine D2 receptors.

, 2006
Contains fulltext : 50736.pdf (Publisher’s version ) (Closed access)Dopaminergic agonists, such as apomorphine and amphetamine, have been shown to drastically reduce prepulse inhibition of the acoustic startle reflex. The effects of the
Elst, M.C.J. van der, Cools, A.R., Ellenbroek, A.A.   +2 more
core   +1 more source

Effect of Aripiprazole on 5-HT2Receptor–mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats

Journal of Pharmacological Sciences, 2008
Aripiprazole, an atypical antipsychotic drug, is a D2dopamine–receptor partial agonist, but also has affinity to several serotonin receptors (5-HT1A,2A,2C,7).
Shuntaro Kohnomi, Katsuya Suemaru, Hiromu Kawasaki, Hiroaki Araki   +3 more
doaj   +1 more source

Neuronal subset-specific Pten-deficient mice do not exhibit deficits in sensorimotor gating processes [version 3; peer review: 1 approved, 2 approved with reservations]

F1000Research, 2020
Background: Deficits in sensorimotor gating have been reported in individuals with autism spectrum disorder (ASD), as well as in ASD murine models. However, this behavior has not been examined in the neuronal subset-specific (NS)-Pten knockout (KO) model
Matthew S. Binder, Joaquin N. Lugo, Suzanne O. Nolan   +2 more
doaj   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

Glycine and GABAA receptors mediate tonic and phasic inhibitory processes that contribute to prepulse inhibition in the goldfish startle network

Frontiers in Neural Circuits, 2015
Prepulse inhibition (PPI) is understood as an inhibitory process that attenuates sensory flow during early stages (20-1000ms) of information processing. Here, we applied in vivo electrophysiology and pharmacology to determine if prepulse inhibition (PPI)
Paul C.P. Curtin, Thomas ePreuss
doaj   +1 more source