Results 61 to 70 of about 990,733 (166)

Animals models of maladaptive traits: Disorders in sensorimotor gating and attentional quantifiable responses as possible endophenotypes

Frontiers in Psychology, 2016
Traditional diagnostic scales are based on a number of symptoms to evaluate and classify mental diseases. In many cases, this process becomes subjective, since the patient must calibrate the magnitude of his/her symptoms and therefore the severity of his/
Juan Pedro Vargas, Estrella eDiaz, Manuel ePortavella, Juan Carlos López   +3 more
doaj   +1 more source

Differential Functional Connectivity Between Hippocampus and Prefrontal Cortex Is Associated With Heterogeneity in Open Field Exploration and Is Disrupted Following Maternal Immune Activation

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT A common paradigm in behavioral neuroscience involves recording neural activity from freely moving rodents as they forage in an open field. This procedure is often used in studies investigating spatial navigation, where recording is conducted in regions such as the hippocampus and entorhinal cortex.
Robert G. K. Munn, Desiree D. Dickerson, Amy R. Wolff, David K. Bilkey   +3 more
wiley   +1 more source

Reflex Excitability Regulates Prepulse Inhibition

, 2000
Presentation of a weak stimulus, a prepulse, before a reflex-evoking stimulus decreases the amplitude of the reflex response relative to reflex amplitude evoked without a preceding prepulse.
Kavita R. Peshori, Eva Sahay, Ramesh Gopalaswamy, Craig Evinger, Edward J. Schicatano   +4 more
core   +1 more source

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome

Neurobiology of Disease, 2011
Fragile X syndrome, the most common form of inherited intellectual disability, is caused by a lack of FMRP, which is the product of the Fmr1 gene. FMRP is an RNA-binding protein and a component of RNA-granules found in the dendrites of neurons.
Josien Levenga, Shigemi Hayashi, Femke M.S. de Vrij, Sebastiaan K. Koekkoek, Herma C. van der Linde, Ingeborg Nieuwenhuizen, Cheng Song, Ronald A.M. Buijsen, Andreea S. Pop, Baltazar GomezMancilla, David L. Nelson, Rob Willemsen, Fabrizio Gasparini, Ben A. Oostra   +13 more
doaj   +1 more source

Adolescent Exposure to a THC‐Rich Cannabis Extract Produces Genotype‐Dependent Effects on Cognition and Glial Morphology in Serine Racemase Mutant Mice

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
Adolescent exposure to a THC‐rich cannabis extract produced genotype‐dependent, contrasting effects in mice. In wild‐type animals, it altered behavior and brain glial cell structure, whereas in mice with a genetic deficiency in serine racemase, a model of impaired NMDA receptor signaling relevant to schizophrenia, it prevented cognitive and ...
Igor F. Rangel, Melissa Chaves, Iohanna Pagnoncelli, Isabelle Medeiros, Felipe Pinheiro, Lorena Fortuna, Luiza Castello‐Branco, Ernesto Diaz Roch, Virgínia Martins Carvalho, Flavia Regina Souza Lima, Rogério Panizzutti, Luciana Romão   +11 more
wiley   +1 more source

Voltage‐gated calcium channel activity of gonadotropin‐releasing hormone (GnRH) neurons is altered by age and by prenatal androgen exposure in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), a common cause of infertility, is marked by persistently high luteinizing hormone (LH) pulse frequency, presumably driven by high‐frequency GnRH pulses. Prenatally androgenized (PNA) mice mimic neuroendocrine PMOS symptoms including high LH‐pulse frequency.
Xi Chen, Jennifer Jaime, R. Anthony DeFazio, Suzanne M. Moenter   +3 more
wiley   +1 more source

Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning

Journal of Pharmacological Sciences, 2010
.: Hyper-signaling of the epidermal growth factor receptor family (ErbB) is implicated in the pathophysiology of schizophrenia. Various quinazoline inhibitors targeting ErbB1 or ErbB2 – 4 have been developed as anti-cancer agents and might be useful for ...
Makoto Mizuno, Yuriko Iwakura, Masako Shibuya, Yingjun Zheng, Takeyoshi Eda, Taisuke Kato, Yohei Takasu, Hiroyuki Nawa   +7 more
doaj   +1 more source

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger, Lilla Lankovics, István Dudás, Tünde Bárkai, Zsófia Szász, Mirjam Balbisi, Anthony Yan‐Tang Wu, Krisztina V. Vukman, Kelsey Fletcher, Attila Csomos, Zoltán Mucsi, Edina Bugyik, Csaba Cserép, Ádám Dénes, Szilvia Bősze, Lilla Turiák, Charles Pin‐Kuang Lai, Edit I. Buzás, Tamás Visnovitz   +18 more
wiley   +1 more source

A Stopped‐Flow Instrument for Millisecond Timescale Reaction Monitoring on a Standard NMR Spectrometer

Magnetic Resonance in Chemistry, Volume 64, Issue 8, Page 711-728, August 2026.
A new stopped‐flow instrument allows kinetic measurements of reactions 10 milliseconds after initiating them by mixing in a flow cell inserted into a standard NMR probe and spectrometer. High‐speed video, pressure and NMR line‐shape data are used to characterise mixing and stopping, and a protodeboronation reaction with a 5‐millisecond half‐life used ...
Andrew M. R. Hall, Edward J. King, Lloyd A. L. Mitchell, George A. Steedman, Stuart Johnstone, Clark Landis, Guy C. Lloyd‐Jones   +6 more
wiley   +1 more source

Levetiracetam inhibits the Na+ HCO3− transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim The Na+‐dependent Cl−/HCO3− exchanger Ncbe/NBCn2 (Slc4a10) constitutes a major basolateral HCO3− uptake pathway in the choroid plexus and contributes to cerebrospinal fluid secretion and pH regulation. This study examined whether levetiracetam inhibits Ncbe/NBCn2‐mediated transport and alters cerebrospinal fluid acid–base balance ...
Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier   +4 more
wiley   +1 more source